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Immunohistochemistry of Terrien's and Mooren's Corneal Degeneration
Juan S. Lopez, MD;
Francis W. Price, Jr, MD;
Scott M. Whitcup, MD;
Qian Li, MD;
Marc de Smet, MD;
Chi-Chao Chan, MD
Arch Ophthalmol. 1991;109(7):988-992.
Abstract
• Lamellar keratoplasty specimens from a patient with Terrien's marginal degeneration and a patient with Mooren's ulcer were compared using routine histopathologic and immunohistochemical staining with an avidin-biotin-peroxidase complex. Less than 25% of the resident cells in the Terrien's marginal degeneration specimen expressed major histocompatibility class II antigens compared with 75% to 100% of the resident cells in the Mooren's ulcer specimen. The ratio of CD4 cells (T-helper/inducer) to CD8 cells (T-suppressor/cytotoxic cells) in the Terrien's marginal degeneration specimen was almost 1:1 compared with 2.4:1 in the Mooren's ulcer specimen. In addition, less than 5% of the infiltrating cells from the Terrien's marginal degeneration specimen stained positive for CD22 (B cells), compared with 25% to 50% from the Mooren's ulcer specimen. These data may help explain why Terrien's marginal degeneration runs a more benign course than does Mooren's ulcer and provides a rationale for the use of immunosuppressive drugs to treat Mooren's ulcer.
Author Affiliations
From the Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Md (Drs Lopez, Whitcup, Li, de Smet, and Chan), and the Cornea Research Foundation of America, Indianapolis, Ind (Dr Price).
Footnotes
Accepted for publication March 22, 1991.
Reprint requests to the Laboratory of Immunology, National Eye Institute, Bldg 10, Room ION 202, Bethesda, MD 20892 (Dr Lopez).
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