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Histologic Features of Human Orbicularis Oculi Treated With Botulinum A Toxin
Cheryl P. Harris, MD;
Kathy Alderson, MD;
Jonathan Nebeker;
John B. Holds, MD;
Richard L. Anderson, MD
Arch Ophthalmol. 1991;109(3):393-395.
Abstract
• To evaluate muscle histologic features in humans following therapeutic botulinum toxin injections, we studied orbicularis oculi from 11 patients with blepharospasm; nine had previously received botulinum toxin injections and two had not. All muscles had comparable variability in muscle fiber diameter, with no necrosis, inflammation, denervation, or consistent alterations in muscle fiber internal architecture. Botulinum toxin produces no persistent histologic changes in human muscle fibers.
Author Affiliations
From the Department of Neurology (Drs Harris and Alderson) and the Division of Oculoplastic Surgery, Department of Ophthalmology (Dr Anderson), University of Utah School of Medicine, Salt Lake City; Neurology Division, Veterans Administration Medical Center, Salt Lake City (Dr Alderson and Mr Nebeker); and the Department of Ophthalmology, University of Texas Medical Branch, Galveston (Dr Holds). Dr Holds is currently with Bethesda Eye Institute, St Louis (Mo) University; Mr Nebeker is currently with the University of Pennsylvania School of Medicine, Philadelphia.
Footnotes
Accepted for publication October 23, 1990.
Read in part before the 66th meeting of the American Association of Neuropathologists, San Francisco, Calif, June 15, 1990.
Reprint requests to the Department of Neurology, University of Utah Medical Center, 50 N Medical Drive, Salt Lake City, UT 84132 (Dr Alderson).
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