Endogenous Pseudallescheria boydii endophthalmitis. Clinicopathologic findings in two cases [published erratum of serious dosage error appears in Arch Ophthalmol 1992 Apr;110(4):449]
J. D. Pfeifer, M. G. Grand, M. A. Thomas, A. R. Berger, M. J. Lucarelli and M. E. Smith
Department of Pathology, Barnes Hospital, Washington University Medical Center, St Louis, MO 63110.
Two cases of endogenous Pseudallescheria boydii endophthalmitis are
presented. One patient had severe pulmonary fibrosis but no history of
ocular trauma and no clinical or laboratory evidence of immunocompromise.
Despite therapy with repeated intravitreal miconazole nitrate injections
and systemic fluconazole, enucleation of the globe was required, and the
patient eventually died with disseminated pseudallescheriasis. The other
patient was an immunosuppressed cardiac transplant recipient who also
received systemic fluconazole therapy. The infected eye eventually required
evisceration, but there was no evidence of disseminated pseudallescheriasis
before his death of unrelated causes.
