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Deborah I. Friedman, MD; Eddie H. Hu, MD; Alfredo A. Sadun, MD, PhD

Arch Ophthalmol. 1991;109(12):1679-1680.

Abstract
• We describe three patients who experienced several types of visual problems while receiving interleukin 2 therapy for melanoma or lymphoma. Their symptoms included diplopia, binocular negative scotomata, scintillating scotomata, and palinopsia. All symptoms eventually resolved following discontinuation of therapy. It appears that focal neurologic deficits that affect the visual system may complicate interleukin 2 administration.

Author Affiliations
From the Doheny Eye Institute and the Departments of Ophthalmology and Neurological Surgery (Drs Friedman and Sadun) and Internal Medicine (Dr Hu), University of Southern California School of Medicine, Los Angeles. Dr Friedman is now with the Department of Neurology and Ophthalmology, SUNY Health Science Center, Syracuse, NY.

Footnotes
Accepted for publication July 3, 1991.

Reprint requests to Department of Ophthalmology, University of Southern California, Doheny Eye Institute, 1355 San Pablo St, Los Angeles, CA 90033 (Dr Sadun).

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