This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (29)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Tetsuro Oshika, MD; Makoto Araie, MD; Tetsuya Sugiyama, MD; Masayuki Nakajima, MD; Ikuo Azuma, MD

Arch Ophthalmol. 1991;109(11):1569-1574.

Abstract
• We investigated the effects of topical administration of bunazosin hydrochloride, a new selective ₁-adrenergic antagonist, on intraocular pressure and aqueous humor dynamics in normal human eyes. In the single-dose study, all concentrations of bunazosin (0.025%, 0.05%, 0.1%, and 0.2%) significantly lowered intraocular pressure in a concentration-dependent manner. Administration of multiple doses of 0.1% bunazosin revealed no occurrence of tachyphylaxis after 1 week. Single application of 0.1% bunazosin had no significant influence on aqueous flow rate, tonographic outflow facility, or episcleral venous pressure, suggesting that bunazosin reduces intraocular pressure by increasing uveoscleral outflow. Aqueous protein concentration was found to be unaltered by bunazosin, indicating that blood-aqueous barrier permeability to protein molecules remained unchanged. We conclude that bunazosin may be a possible new antiglaucoma agent with a mechanism of action different from those currently in use for treating ocular hypertension.

Author Affiliations
From the Departments of Ophthalmology, University of Tokyo (Japan) School of Medicine, (Drs Oshika and Araie), and Osaka (Japan) Medical College (Drs Sugiyama, Nakajima, and Azuma).

Footnotes
Accepted for publication July 3, 1991.

Reprint requests to Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan (Dr Oshika).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Analysis of {alpha}2-adrenergic Receptors and Effect of Brimonidine on Matrix Metalloproteinases and Their Inhibitors in Human Ciliary Body
Ooi et al.
IOVS 2009;50:4237-4243.
ABSTRACT | FULL TEXT  

Intraocular Pressure-Lowering Effects and Safety of Topical Administration of a Selective ROCK Inhibitor, SNJ-1656, in Healthy Volunteers
Tanihara et al.
Arch Ophthalmol 2008;126:309-315.
ABSTRACT | FULL TEXT  

The IOP-lowering effects and mechanism of action of tafluprost in prostanoid receptor-deficient mice
Ota et al.
Br J Ophthalmol 2007;91:673-676.
ABSTRACT | FULL TEXT  

Human Trabecular Meshwork Cells Express Functional Serotonin-2A (5HT2A) Receptors: Role in IOP Reduction.
Sharif et al.
IOVS 2006;47:4001-4010.
ABSTRACT | FULL TEXT  

The Effects of Prostaglandin Analogues on IOP in Prostanoid FP-Receptor-Deficient Mice
Ota et al.
IOVS 2005;46:4159-4163.
ABSTRACT | FULL TEXT  

Effects of topical nipradilol, a beta blocking agent with alpha blocking and nitroglycerin-like activities, on intraocular pressure and aqueous dynamics in humans
Kanno et al.
Br J Ophthalmol 2000;84:293-299.
ABSTRACT | FULL TEXT