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Effect of Bunazosin Hydrochloride on Intraocular Pressure and Aqueous Humor Dynamics in Normotensive Human Eyes
Tetsuro Oshika, MD;
Makoto Araie, MD;
Tetsuya Sugiyama, MD;
Masayuki Nakajima, MD;
Ikuo Azuma, MD
Arch Ophthalmol. 1991;109(11):1569-1574.
Abstract
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We investigated the effects of topical administration of bunazosin hydrochloride, a new selective 1-adrenergic antagonist, on intraocular pressure and aqueous humor dynamics in normal human eyes. In the single-dose study, all concentrations of bunazosin (0.025%, 0.05%, 0.1%, and 0.2%) significantly lowered intraocular pressure in a concentration-dependent manner. Administration of multiple doses of 0.1% bunazosin revealed no occurrence of tachyphylaxis after 1 week. Single application of 0.1% bunazosin had no significant influence on aqueous flow rate, tonographic outflow facility, or episcleral venous pressure, suggesting that bunazosin reduces intraocular pressure by increasing uveoscleral outflow. Aqueous protein concentration was found to be unaltered by bunazosin, indicating that blood-aqueous barrier permeability to protein molecules remained unchanged. We conclude that bunazosin may be a possible new antiglaucoma agent with a mechanism of action different from those currently in use for treating ocular hypertension.
Author Affiliations
From the Departments of Ophthalmology, University of Tokyo (Japan) School of Medicine, (Drs Oshika and Araie), and Osaka (Japan) Medical College (Drs Sugiyama, Nakajima, and Azuma).
Footnotes
Accepted for publication July 3, 1991.
Reprint requests to Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan (Dr Oshika).
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