PhXA34, a new potent ocular hypotensive drug. A study on dose-response relationship and on aqueous humor dynamics in healthy volunteers
A. Alm and J. Villumsen
Department of Ophthalmology, University Hospital, Umea, Sweden.
The prostaglandin analogue PhXA34 was tested in two studies in normal human
eyes; 1, 3, and 10 micrograms of PhXA34 reduced the intraocular pressure by
about 2, 3, and 4 mm Hg, respectively, 6 to 10 hours after a single topical
dose. The only side effect observed was a slight conjunctival hyperemia
after 10 micrograms of PhXA34. In a second study we determined the effect
of 10 micrograms of PhXA34 once daily for 7 days on intraocular pressure,
outflow facility, aqueous flow, blood-aqueous barrier permeability, ocular
discomfort, and hyperemia. The mean intraocular pressure was below 9 mm Hg
12 hours post dose. About one third of the intraocular pressure reduction
could be explained by increased outflow facility. Aqueous flow was
unaffected. Treatment caused a 21% increase in aqueous fluorescence 1 hour
after an oral dose of fluorescein. Mild ocular discomfort and some
hyperemia were initially observed in half of the subjects, but frequency
and magnitude of these side effects declined during the study.
Can NSAIDs and prostaglandin analogues be combined?
Alm
Br. J. Ophthalmol. 2006;90:259-260.
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Tonometric Changes of Latanoprost-Induced Intraocular Pressure Reduction after Photorefractive Keratectomy
Tamburrelli et al.
IOVS 2004;45:846-850.
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Paradoxical Intraocular Pressure Elevation After Combined Therapy With Latanoprost and Bimatoprost
Herndon et al.
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From PGF2{{alpha}}-Isopropyl Ester to Latanoprost: A Review of the Development of Xalatan The Proctor Lecture
Stjernschantz
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Effect of Latanoprost on Regional Blood Flow and Capillary Permeability in the Monkey Eye
Stjernschantz et al.
Arch Ophthalmol 1999;117:1363-1367.
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Assessment of Ocular Hypotensive Mechanisms and Additivity of Antiglaucoma Drugs in Humans
Kaufman
Arch Ophthalmol 1999;117:673-674.
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Effect of 8-iso Prostaglandin E2 on Aqueous Humor Dynamics in Monkeys
Wang et al.
Arch Ophthalmol 1998;116:1213-1216.
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A double masked comparison of the intraocular pressure reducing effect of latanoprost 0.005% and 0.001% administered once daily in open angle glaucoma and ocular hypertension
Fristrom and Nilsson
Br. J. Ophthalmol. 1997;81:867-870.
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Effects on IOP restoration and blood-aqueous barrier after long term treatment with latanoprost in open angle glaucoma and ocular hypertension
Linden et al.
Br. J. Ophthalmol. 1997;81:370-372.
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