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A Multicenter Study

Neal A. Sher, MD; Varda Chen, MD; Richard A. Bowers, MD; Jonathan M. Frantz, MD; David C. Brown, MD; Richard Eiferman, MD; Steven S. Lane, MD; Paula Parker, COMT; Charles Ostrov, MD; Donald Doughman, MD; Emmett Carpel, MD; Ralph Zabel, MD; Todd Gothard, MD; Richard L. Lindstrom, MD

Arch Ophthalmol. 1991;109(11):1525-1530.

Abstract
• Photorefractive keratectomy was performed at three centers using the 193-nm excimer laser on 31 sighted myopic eyes. Preoperative refractive errors (spherical equivalent) ranged from –12.00 to –4.00 diopters (D) (mean, –6.49 ± 1.75 D). Peribulbar anesthesia, a 5.2- to 6.0-mm beam diameter, and topical corticosteroids were used for up to 6 months after surgery. The epithelium healed within 3 to 4 days, and all patients returned to their best corrected visual acuity within 1 line of their preoperative acuity. There was minimal subepithelial reticular haze, peaking at 3 weeks and diminishing over the next 3 to 4 months, which was not felt to be visually significant. At 6 months, the average residual refractive error was 1.85 ± 2.5 D. Sixty-eight percent of eyes were corrected within 2 D and 55% within 1 D of attempted correction. There was no significant change in astigmatism, contrast sensitivity, corneal sensation, or endothelial cell counts. This preliminary work shows that photorefractive keratectomy has promise in the reduction of moderate myopia.

Author Affiliations
From the Excimer Research Group, Phillips Eye Institute, Metropolitan Mt Sinai Medical Center, and the Department of Ophthalmology, University of Minnesota School of Medicine, Minneapolis (Drs Sher, Chen, Bowers, Lane, Ostrov, Doughman, Carpel, Zabel, Gothard, and Lindstrom and Ms Parker); the Eye Center of Florida, Fort Myers (Drs Frantz and Brown); and the Department of Ophthalmology, University of Louisville and Veterans Affairs Medical Center, Louisville, Ky (Dr Eiferman).

Footnotes
Accepted for publication June 17, 1991.

Presented in part at the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 2, 1991, and the American Ophthalmological Society, Pebble Beach, Calif, May 20, 1991.

Reprint requests to Phillips Eye Institute, 2215 Park Ave, Minneapolis, MN 55404 (Dr Sher).

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