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COMS Report No. 1

The Collaborative Ocular Melanoma Study Group

Arch Ophthalmol. 1990;108(9):1268-1273.

Abstract
• In the 3-year period during which patients were enrolled into the Collaborative Ocular Melanoma Study, 413 eyes with clinical diagnoses of choroidal melanoma were examined histopathologically as of December 31, 1989. Four hundred eleven of these eyes were found to be diagnosed correctly. One eye, removed after preoperative external beam radiation, was found to have a hemangioma. The second eye, removed after radioactive iodine plaque placement, was described as a magnocellular nevus (melanocytoma) by four of the five pathologists on the Collaborative Ocular Melanoma Study Pathology Review Committee. The Collaborative Ocular Melanoma Study misdiagnosis rate of 0.48% is the lowest ever reported. The major challenge with regard to posterior uveal melanomas is no longer that of correct diagnosis but rather determination of the optimal treatment.

Footnotes
Accepted for publication March 31, 1990.

Prepared by Daniel M. Albert, MD, Dennis M. Marcus, MD, and the COMS Pathology Review Committee. A list of all centers, selected personnel at each, and selected committees appears on page 1272.

Reprint requests to David G. Cogan Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St, Boston, MA 02114 (Dr Albert).

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