Topical ultraviolet light-absorbing chromophore protects against experimental photokeratitis

doi:10.1001/archopht.108.8.1142

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Vol. 108 No. 8, August 1990

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Topical ultraviolet light-absorbing chromophore protects against experimental photokeratitis

J. B. Oldenburg, D. C. Gritz and P. J. McDonnell
Doheny Eye Institute, Los Angeles, CA 90033.

Ultraviolet radiation may play a causative role in a number of human ocular and dermatologic conditions; reduction of environmental UV light exposure may decrease their incidence. We investigated the effects of two different UV light-absorbing chromophores, octyl methoxycinnamate (Parsol-MCX) and butyl methoxydibenzoylmethane (Parsol-1798) on corneal UV light transmittance, and evaluated topically applied Parsol-MCX for its protective effect against experimental UV light-induced keratitis in New Zealand white rabbits. Both Parsol-1789 (UV-A light absorber) and Parsol-MCX (UV-B light absorber) are well tolerated by New Zealand white rabbit eyes. Pretreatment with a single drop of Parsol-MCX reproducibly protected against UV light-induced keratitis, apparently by absorbing greater than 75% of UV-B (peak wavelength, 308 nm) irradiation.

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