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  Vol. 108 No. 7, July 1990 TABLE OF CONTENTS
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Optic Nerve Head Extracellular Matrix in Primary Optic Atrophy and Experimental Glaucoma

John C. Morrison, MD; Mary Ellen Dorman-Pease; Gregory R. Dunkelberger, MS; Harry A. Quigley, MD

Arch Ophthalmol. 1990;108(7):1020-1024.


Abstract



• Unilateral glaucomatous optic neuropathy and optic nerve transections were produced in cynomolgous monkeys, and the optic nerve heads were examined by light and electron microscopic immunohistochemistry. Glaucomatous nerve heads showed increased labeling for collagen type IV along the margins of beams in the lamina cribrosa, due to accumulation of basement membrane-like materials. We also noted material in the pores of the laminar beams that labeled with antibodies to collagen types I, III and IV, but not elastin. In transected eyes, increased type IV labeling of laminar beam margins resulted solely from redundant astrocyte basement membranes. Extracellular matrix deposition within laminar pores was not observed following optic nerve transection; hence this may be a selective response to elevated intraocular pressure. This response may alter the biochemical composition of the lamina cribrosa and its function in patients with elevated intraocular pressure.



Author Affiliations



From the Department of Ophthalmology, Oregon Health Sciences University, Portland (Dr Morrison); the Portland Veteran's Administration Medical Center (Dr Morrison); and The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Md (Ms Dorman-Pease, Mr Dunkelberger, and Dr Quigley).


Footnotes



Accepted for publication April 11, 1990.

Presented in part at the 1989 Meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla.

Reprint requests to The Wilmer Institute, B110, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21205 (Dr Quigley).



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