This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Arunan Sivalingam, MD; John Kenney, MS; Gary C. Brown, MD; William E. Benson, MD; Larry Donoso, MD, PhD

Arch Ophthalmol. 1990;108(6):869-872.

Abstract
• A two-site enzyme-linked immunosorbent assay was used to quantitate levels of basic fibroblast growth factor in the vitreous from 36 patients undergoing vitrectomy for a variety of retinal conditions, including proliferative diabetic retinopathy, macular pucker, and retinal detachment with and without proliferative vitreoretinopathy. Basic fibroblast growth factor levels ranged from undetectable to 52 ng/mL. In patients with proliferative diabetic retinopathy, basic fibroblast growth factor levels were greater than or equal to 30 ng/mL in 8 of 17 specimens. Of the 8 patients with elevated basic fibroblast growth factor levels, 6 had evidence of active proliferative disease (ie, neovascularization of the disc or iris), whereas in the patients who had undetectable levels only 2 of 9 had evidence of neovascularization of disc and none had neovascularization of the iris. In the rhegmatogenous retinal detachment group, 2 of 10 eyes had elevated basic fibroblast growth factor levels, while none in the macular pucker group had elevated levels. Our study documents increased levels of basic fibroblast growth factor in vitreous specimens from patients with proliferative diabetic retinopathy, particularly those with active proliferative retinopathy. The role of basic fibroblast growth factor in the pathogenesis of various retinal disease entities is discussed.

Author Affiliations
From the Retina Service, Wills Eye Hospital and Thomas Jefferson University, Philadelphia, Pa (Drs Sivalingam, Brown, Benson, and Donoso), and Syntex Research, Palo Alto, Calif (Mr Kenney). Dr Donoso is the Thomas Duane Professor of Ophthalmology, Jefferson Medical College, Thomas Jefferson University.

Footnotes
Accepted for publication January 18, 1990.

Reprint requests to Wills Eye Hospital, Philadelphia, PA 19107 (Dr Donoso).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells
Browning et al.
Br J Ophthalmol 2008;92:1003-1008.
ABSTRACT | FULL TEXT  

Cytokine Profile of Peripheral Blood in Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy
Lee et al.
Annals of Clinical & Laboratory Science 2008;38:361-367.
ABSTRACT | FULL TEXT  

Comparison between the Gene Expression Profile of Human Muller Cells and Two Spontaneous Muller Cell Lines
Lupien et al.
IOVS 2007;48:5229-5242.
ABSTRACT | FULL TEXT  

A chronic grey matter penumbra, lateral microvascular intussusception and venous peduncular avulsion underlie diabetic vitreous haemorrhage
McLeod
Br J Ophthalmol 2007;91:677-689.
ABSTRACT | FULL TEXT  

Time-Lapse Imaging of Vitreoretinal Angiogenesis Originating from Both Quiescent and Mature Vessels in a Novel Ex Vivo System
Murakami et al.
IOVS 2006;47:5529-5536.
ABSTRACT | FULL TEXT  

Involvement of Protein Kinase CK2 in Angiogenesis and Retinal Neovascularization
Ljubimov et al.
IOVS 2004;45:4583-4591.
ABSTRACT | FULL TEXT  

Risk evaluation of outcome of vitreous surgery for proliferative diabetic retinopathy based on vitreous level of vascular endothelial growth factor and angiotensin II
Funatsu et al.
Br J Ophthalmol 2004;88:1064-1068.
ABSTRACT | FULL TEXT  

Expression and Localization of Tenomodulin, a Transmembrane Type Chondromodulin-I-Related Angiogenesis Inhibitor, in Mouse Eyes
Oshima et al.
IOVS 2003;44:1814-1823.
ABSTRACT | FULL TEXT  

Retinal Oxygen: Fundamental and Clinical Aspects
Wangsa-Wirawan and Linsenmeier
Arch Ophthalmol 2003;121:547-557.
ABSTRACT | FULL TEXT  

Diabetes Can Alter the Signal Transduction Pathways in the Lens of Rats
Zatechka et al.
Diabetes 2003;52:1014-1022.
ABSTRACT | FULL TEXT  

Neurotrophic Factor Receptors in Epiretinal Membranes After Human Diabetic Retinopathy
Harada et al.
Diabetes Care 2002;25:1060-1065.
ABSTRACT | FULL TEXT  

Suppressed Expression of Tubedown-1 in Retinal Neovascularization of Proliferative Diabetic Retinopathy
Gendron et al.
IOVS 2001;42:3000-3007.
ABSTRACT | FULL TEXT  

Expression of Prolactin Gene and Secretion of Prolactin by Rat Retinal Capillary Endothelial Cells
Ochoa et al.
IOVS 2001;42:1639-1645.
ABSTRACT | FULL TEXT  

Mechanisms of Hepatocyte Growth Factor-Induced Retinal Endothelial Cell Migration and Growth
Cai et al.
IOVS 2000;41:1885-1893.
ABSTRACT | FULL TEXT  

Inhibition of Rat Corneal Angiogenesis by 16-kDa Prolactin and by Endogenous Prolactin-like Molecules
Duenas et al.
IOVS 1999;40:2498-2505.
ABSTRACT | FULL TEXT  

Increased Interleukin-6 in Aqueous Humor of Neovascular Glaucoma
Chen et al.
IOVS 1999;40:2627-2632.
ABSTRACT | FULL TEXT  

Comparison of the levels of hepatocyte growth factor and vascular endothelial growth factor in aqueous fluid and serum with grades of retinopathy in patients with diabetes mellitus
Shinoda et al.
Br J Ophthalmol 1999;83:834-837.
ABSTRACT | FULL TEXT  

Ocular Neovascularization : Clarifying Complex Interactions
Neely and Gardner
Am. J. Pathol. 1998;153:665-670.
FULL TEXT  

Basic Fibroblast Growth Factor Is Neither Necessary nor Sufficient for the Development of Retinal Neovascularization
Ozaki et al.
Am. J. Pathol. 1998;153:757-765.
ABSTRACT | FULL TEXT  

Transforming Growth Factor {beta}2 in the Vitreous in Proliferative Diabetic Retinopathy
Hirase et al.
Arch Ophthalmol 1998;116:738-741.
ABSTRACT | FULL TEXT  

Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders
Cassidy et al.
Br J Ophthalmol 1998;82:181-185.
ABSTRACT | FULL TEXT  

Localisation of vascular endothelial growth factor and its receptors to cells of vascular and avascular epiretinal membranes
Chen et al.
Br J Ophthalmol 1997;81:919-926.
ABSTRACT | FULL TEXT  

Elevated {gamma}-Aminobutyric Acid, Glutamate, and Vascular Endothelial Growth Factor Levels in the Vitreous of Patients With Proliferative Diabetic Retinopathy
Ambati et al.
Arch Ophthalmol 1997;115:1161-1166.
ABSTRACT  

Increased Levels of Serum Fibroblast Growth Factor-2 in Diabetic Pregnant Women with Retinopathy
Hill et al.
J. Clin. Endocrinol. Metab. 1997;82:1452-1457.
ABSTRACT | FULL TEXT  

Intravitreal growth factors in proliferative diabetic retinopathy: correlation with neovascular activity and glycaemic management
Boulton et al.
Br J Ophthalmol 1997;81:228-233.
ABSTRACT | FULL TEXT  

Increased expression of angiogenic growth factors in age-related maculopathy
Kliffen et al.
Br J Ophthalmol 1997;81:154-162.
ABSTRACT | FULL TEXT  

Vascular Endothelial Growth Factor Is Sufficient to Produce Iris Neovascularization and Neovascular Glaucoma in a Nonhuman Primate
Tolentino et al.
Arch Ophthalmol 1996;114:964-970.
ABSTRACT  

Inhibition of Vascular Endothelial Growth Factor Prevents Retinal Ischemia--Associated Iris Neovascularization in a Nonhuman Primate
Adamis et al.
Arch Ophthalmol 1996;114:66-71.
ABSTRACT  

Glu-96 of Basic Fibroblast Growth Factor Is Essential for High Affinity Receptor Binding
Zhu et al.
J. Biol. Chem. 1995;270:21869-21874.
ABSTRACT | FULL TEXT  

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders
Aiello et al.
NEJM 1994;331:1480-1487.
ABSTRACT | FULL TEXT  

Vascular Endothelial Growth Factor -- Its Role in Retinal Vascular Proliferation
Frank
NEJM 1994;331:1519-1520.
FULL TEXT  

Detection of Vascular Endothelial Growth Factor Messenger RNA and Vascular Endothelial Growth Factor-like Activity in Proliferative Diabetic Retinopathy
Malecaze et al.
Arch Ophthalmol 1994;112:1476-1482.
ABSTRACT  

Acidic and basic FGF in ocular media and lens: implications for lens polarity and growth patterns
Schulz et al.
Development 1993;118:117-126.
ABSTRACT  

Altered Distribution of Basic Fibroblast Growth Factor in Diabetic Retinopathy
Hanneken et al.
Arch Ophthalmol 1991;109:1005-1011.
ABSTRACT  

Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor
Stellmach et al.
Proc. Natl. Acad. Sci. USA 2001;98:2593-2597.
ABSTRACT | FULL TEXT