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Howard M. Leibowitz, MD; Sergio Morello, Jr, MD; Michael Stern, PhD; Allan Kupferman, PhD

Arch Ophthalmol. 1990;108(5):734-737.

Abstract
• A 9-mm perforating corneal wound was created in one eye of New Zealand albino rabbits, sutured, and treated with mouse-derived epidermal growth factor (1 mg/L), human-derived epidermal growth factor (1.0 mg/L to 100 mg/L), or buffered saline, instilled once, twice, or four times daily. Both mouse-derived epidermal growth factor and human-derived epidermal growth factor significantly increased the tensile strength of full-thickness corneal wounds after 9 days of topical therapy. For human-derived epidermal growth factor, a concentration of 10 mg/L administered twice daily produced the maximal effect. An increase in either the concentration of epidermal growth factor or its frequency of administration failed to induce a further increase in wound strength. Indeed, at a concentration of 100 mg/L, human-derived epidermal growth factor appeared to lose its ability to accelerate healing of full-thickness corneal wounds.

Author Affiliations
From the Departments of Ophthalmology (Drs Leibowitz, Morello, and Kupferman) and Pharmacology (Dr Kupferman), Boston (Mass) University School of Medicine; and Alcon Laboratoratories, Inc, Fort Worth, Tex (Dr Stern).

Footnotes
Accepted for publication on December 20,1989.

Reprint requests to Boston University School of Medicine, 80 E Concord St, Boston, MA 02118 (Dr Leibowitz).

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