Hyperopia in complicated Leber's congenital amaurosis
L. R. Dagi, M. J. Leys, R. M. Hansen and A. B. Fulton
Department of Ophthalmology, Harvard Medical School, Boston, Mass 02115.
We studied the refractive status of 13 children with Leber's congenital
amaurosis. Seven had the disease complicated by neurological or other
systemic abnormalities, while the other 6 patients had only ophthalmic
abnormalities. All 13 patients were hyperopic. The magnitude of hyperopia
did not differ significantly between the complicated and uncomplicated
groups. Therefore, one cannot, as previously suggested, use the presence of
high hyperopia to differentiate an uncomplicated form of Leber's congenital
amaurosis from one complicated by neurologic or other systemic
abnormalities. The concurrence of hyperopia with Leber's congenital
amaurosis should not steer the physician away from careful neurologic
systemic or biochemical evaluation of the child.
