In Vivo Angiogenic Activity of Interleukins

doi:10.1001/archopht.1990.01070060121061

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Vol. 108 No. 4, April 1990

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In Vivo Angiogenic Activity of Interleukins

David BenEzra, MD, PhD; Itzhak Hemo, MD; Genia Maftzir, MSc

Arch Ophthalmol. 1990;108(4):573-576.

Abstract

• Interleukin 1 incorporated into Elvax-40 (ethylene-vinyl-acetatecopolymer consisting of 40% vinyl-acetate by weight) inducesa rapid and strong angiogenic stimulus when implanted in rabbitcorneas at a distance of 2.5 mm from the limbus. A constantand reproducible neovascular stimulus was observed with 5 ngper implant of recombinant human interleukin 1 alpha or 100ng per implant of recombinant human interleukin 1 beta. At theseconcentrations, neither tumor necrosis factor nor interleukin2 induced any neovascular stimulus. These data are interpretedas an indication for the possible role of interleukin 1 in angiogenesisof ocular (and other) tissues. As interleukin 1 is producedby various cells, it is hypothesized that this molecule maybe the "unitarian angiogenic factor."

Author Affiliations

From the Pediatric and Immuno-Ophthalmology Unit and the Laboratory of Ocular Angiogenesis, Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.

Footnotes

Accepted for publication November 28, 1989.

Reprint requests to Department of Ophthalmology, Hadassah UniversityHospital, PO Box 1200, 91120 Jerusalem, Israel (Dr BenEzra).

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