This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (80)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

David BenEzra, MD, PhD; Itzhak Hemo, MD; Genia Maftzir, MSc

Arch Ophthalmol. 1990;108(4):573-576.

Abstract
• Interleukin 1 incorporated into Elvax-40 (ethylene-vinyl-acetate copolymer consisting of 40% vinyl-acetate by weight) induces a rapid and strong angiogenic stimulus when implanted in rabbit corneas at a distance of 2.5 mm from the limbus. A constant and reproducible neovascular stimulus was observed with 5 ng per implant of recombinant human interleukin 1 alpha or 100 ng per implant of recombinant human interleukin 1 beta. At these concentrations, neither tumor necrosis factor nor interleukin 2 induced any neovascular stimulus. These data are interpreted as an indication for the possible role of interleukin 1 in angiogenesis of ocular (and other) tissues. As interleukin 1 is produced by various cells, it is hypothesized that this molecule may be the "unitarian angiogenic factor."

Author Affiliations
From the Pediatric and Immuno-Ophthalmology Unit and the Laboratory of Ocular Angiogenesis, Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.

Footnotes
Accepted for publication November 28, 1989.

Reprint requests to Department of Ophthalmology, Hadassah University Hospital, PO Box 1200, 91120 Jerusalem, Israel (Dr BenEzra).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Potent in Vivo Antiangiogenic Effects of GS-101 (5'-TATCCGGAGGGCTCGCCATGCTGCT-3'), an Antisense Oligonucleotide Preventing the Expression of Insulin Receptor Substrate-1
Al-Mahmood et al.
J. Pharmacol. Exp. Ther. 2009;329:496-504.
ABSTRACT | FULL TEXT  

Dexamethasone Inhibits Interleukin-1{beta}-Induced Corneal Neovascularization: Role of Nuclear Factor-{kappa}B-Activated Stromal Cells in Inflammatory Angiogenesis
Nakao et al.
Am. J. Pathol. 2007;171:1058-1065.
ABSTRACT | FULL TEXT  

IL-1beta Disrupts Postnatal Lung Morphogenesis in the Mouse
Bry et al.
Am. J. Respir. Cell Mol. Bio. 2007;36:32-42.
ABSTRACT | FULL TEXT  

Downregulation of IRS-1 Expression Causes Inhibition of Corneal Angiogenesis
Berdugo et al.
IOVS 2005;46:4072-4078.
ABSTRACT | FULL TEXT  

Inhibition of Tumor Necrosis Factor-{alpha} Improves Physiological Angiogenesis and Reduces Pathological Neovascularization in Ischemic Retinopathy
Gardiner et al.
Am. J. Pathol. 2005;166:637-644.
ABSTRACT | FULL TEXT  

Microarray Analysis of Corneal Fibroblast Gene Expression after Interleukin-1 Treatment
Mahajan et al.
IOVS 2002;43:2143-2151.
ABSTRACT | FULL TEXT  

Increase in Prostaglandin E2 Production by Interleukin-1{beta} in Arterial Smooth Muscle Cells Derived From Patients With Moyamoya Disease
Yamamoto et al.
Circ. Res. 1999;85:912-918.
ABSTRACT | FULL TEXT  

The Potential Angiogenic Role of Macrophages in the Formation of Choroidal Neovascular Membranes
Oh et al.
IOVS 1999;40:1891-1898.
ABSTRACT | FULL TEXT  

Pharmacological Effects of SB 220025, a Selective Inhibitor of P38 Mitogen-Activated Protein Kinase, in Angiogenesis and Chronic Inflammatory Disease Models
Jackson et al.
J. Pharmacol. Exp. Ther. 1998;284:687-692.
ABSTRACT | FULL TEXT  

Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1beta in Rat Aortic Smooth Muscle Cells
Li et al.
J. Biol. Chem. 1995;270:308-312.
ABSTRACT | FULL TEXT  

Therapeutic Angiogenesis
Hockel et al.
Arch Surg 1993;128:423-429.
ABSTRACT