This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (43)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

J. Donald M. Gass, MD; Richard G. Gieser, MD; C. P. Wilkinson, MD; Donald E. Beahm, MD; Scott E. Pautler, MD

Arch Ophthalmol. 1990;108(4):527-533.

Abstract
• The development of multiple, round or oval, subtle, red patches at the level of the pigment epithelium in the posterior ocular fundus and their striking early hyperfluorescence angiographically are characteristic features of the bilateral diffuse uveal melanocytic proliferation syndrome. They may be accompanied by severe visual loss and may antedate the appearance of multiple melanocytic tumors, retinal detachment, and cataract in these patients with occult systemic carcinomas. These hyperfluorescent patches are caused by focal damage to the pigment epithelium overlying an intact choriocapillaris and diffuse benign nonpigmented uveal melanocytic infiltration of the outer choroid. We suggest that outer retinal damage may not be primarily caused by melanocytic proliferation, but rather by toxic and immune factors generated by interaction between a systemic carcinoma and congenital melanocytosis of the uveal tract. We report the longest survivor of this disorder to date (102 months).

Author Affiliations
From the Departments of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Fla (Dr Gass); Loyola University of Chicago Stritch School of Medicine, Maywood, Ill (Dr Gieser); Dean A. McGee Eye Institute, Oklahoma City, Okla (Dr Wilkinson); University of Kansas, Kansas City (Dr Beahm); and University of South Florida, Tampa (Dr Pautler).

Footnotes
Accepted for publication December 29, 1989.

Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Unilateral diffuse uveal melanocytic proliferation (DUMP)
Reddy and Finger
Br J Ophthalmol 2007;91:1726-1727.
FULL TEXT  

Uveal and Cutaneous Involvement in Paraneoplastic Melanocytic Proliferation
Singh et al.
Arch Ophthalmol 2003;121:1637-1640.
FULL TEXT  

Case 2-2002- A 58-Year-Old Woman with Unilateral Loss of Vision and Postmenopausal Bleeding
D'Amico and Dryja
NEJM 2002;346:189-195.
FULL TEXT  

Leopard-Spot Pattern of Yellowish Subretinal Deposits in Central Serous Chorioretinopathy
Iida et al.
Arch Ophthalmol 2002;120:37-42.
ABSTRACT | FULL TEXT  

Bilateral optic neuropathy with IgG{kappa} multiple myeloma improved after myeloablative chemotherapy
Lieberman et al.
Neurology 1999;52:414-414.
ABSTRACT | FULL TEXT  

Early Lesions of Bilateral Diffuse Melanocytic Proliferation
Leys et al.
Arch Ophthalmol 1991;109:1590-1594.
ABSTRACT