Ultrastructural localization of extracellular matrix components in human retinal vessels and Bruch's membrane
A. Das, R. N. Frank, N. L. Zhang and T. J. Turczyn
Kresge Eye Institute, Wayne State University School of Medicine, MI 48201.
We have used the electron microscopic immunogold technique to localize
precisely various extracellular matrix components in human retinal vessels
and Bruch's membrane. Collagen types IV and V, laminin, and heparan sulfate
proteoglycan core protein were localized in basement membranes of retinal
capillaries. In addition to the capillary basement membrane components,
collagen types I and III and fibronectin were found in the basement
membranes of retinal arterioles and venules. The basement membranes of
choriocapillaries and retinal pigment epithelial cells in Bruch's membrane
also showed a similar distribution of the retinal capillary basement
membrane components. Both the inner and outer collagenous layers of Bruch's
membrane contained collagen types I and III along with fibronectin, whereas
collagen type VI was mostly limited to the central elastic lamina. The
precise localization and distribution of various extracellular matrix
components in human retinal vessels and Bruch's membrane may be important
for understanding their normal function as well as their alteration in
disease.
Collagen Distribution in the Human Vitreoretinal Interface
Ponsioen et al.
IOVS 2008;49:4089-4095.
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Laminin {beta}1 and {gamma}1 Containing Laminins Are Essential for Basement Membrane Integrity in the Zebrafish Eye
Lee and Gross
IOVS 2007;48:2483-2490.
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Retinal Pigment Epithelial Cells Synthesize Laminins, Including Laminin 5, and Adhere to Them through {alpha}3- and {alpha}6-Containing Integrins
Aisenbrey et al.
IOVS 2006;47:5537-5544.
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Impaired expression of thrombospondin-1 in eyes with age related macular degeneration
Uno et al.
Br. J. Ophthalmol. 2006;90:48-54.
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Iris Pigment Epithelium Attachment to Aged Submacular Human Bruch's Membrane
Itaya et al.
IOVS 2004;45:4520-4528.
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Current Concepts in the Pathogenesis of Age-Related Macular Degeneration
Zarbin
Arch Ophthalmol 2004;122:598-614.
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Retinal Pigment Epithelium Wound Healing in Human Bruch's Membrane Explants
Wang et al.
IOVS 2003;44:2199-2210.
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Distribution of the collagen IV isoforms in human Bruch's membrane
Chen et al.
Br. J. Ophthalmol. 2003;87:212-215.
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Effect of High Glucose on Fibronectin Expression and Cell Proliferation in Trabecular Meshwork Cells
Sato and Roy
IOVS 2002;43:170-175.
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Accumulation of Cholesterol with Age in Human Bruch's Membrane
Curcio et al.
IOVS 2001;42:265-274.
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