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Denis Wakefield, MD, FRACP; Tom H. Stahlberg, PhD; Auli Toivanen, MD; Kaisa Granfors, PhD; Carolyn Tennant

Arch Ophthalmol. 1990;108(2):219-221.

Abstract
• Anterior uveitis is a common inflammatory eye disease associated with the HLA-B27 phenotype. Bacteriologic cofactors have been implicated in the pathogenesis of several diseases associated with HLA-B27. Using a sensitive enzyme-linked immunosorbent assay, we examined the incidence of previous Yersinia infection in a group of 28 consecutive patients with anterior uveitis. Twelve patients had a significantly increased antibody response to Yersinia, 8 of whom were HLA-B27 positive. Eight patients had IgM antibodies, possibly indicative of recent infection. There were no positive Yersinia serologic findings in our control group of 28 subjects, 13 of whom were HLA-B27 positive. A strong association was found between previous Yersinia infection and the development of anterior uveitis in HLA-B27-positive and HLA-B27-negative patients.

Author Affiliations
From the Laboratory of Ocular Immunology, School of Pathology, The University of New South Wales (NSW), Sydney, Australia (Dr Wakefield and Ms Tennant); and the Department of Medical Microbiology, Turku (Finland) University (Drs Stahlberg, Toivanen, and Granfors).

Footnotes
Accepted for publication August 4,1989.

Reprint requests to Department of Immunopathology, The Prince Henry Hospital, PO Box 233, Matraville, New South Wales 2033, Australia (Dr Wakefield).

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