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  Vol. 108 No. 11, November 1990 TABLE OF CONTENTS
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Healing of Excimer Laser Ablated Monkey Corneas

An Immunohistochemical Evaluation

Nirmala SundarRaj, PhD; Michael J. Geiss III; Francisco Fantes, MD; Khalil Hanna, MD; Susan C. Anderson; Keith P. Thompson, MD; Richard A. Thoft, MD; George O. Waring III, MD

Arch Ophthalmol. 1990;108(11):1604-1610.


Abstract



• The healing response of the cornea following excimer laser anterior keratomileusis (a 4-mm-diameter ablation to a depth of 11, 23, or 46 µm) was analyzed immunohistochemically in adult rhesus monkeys. The ablated surface had reepithelialized and the synthesis of type VII collagen (a major component of anchoring fibrils) was evident by 7 days; the reestablishment of a nearly continuous anchoring fibril zone was evident after 12 weeks. Stromal fibroblasts, activated in response to wounding, expressed a fetal antigen for approximately 6 weeks. Although fibronectin and type VII collagen were present only transiently in the regenerating subepithelial stromal matrix in the subepithelial regions, some other alterations, including the presence of type III collagen, increased levels of keratan sulfates, and discontinuities in the anchoring fibril zone were evident even 18 months after wounding. The depths of the regenerated stroma, which were estimated from the depths of remnant staining for type VII collagen in the stromal matrix, generally, but not always, corresponded to the depths of the calculated ablation.



Author Affiliations



From The Eye and Ear Institute of Pittsburgh and the University of Pittsburgh (Pa) School of Medicine (Drs SundarRaj and Thoft, Mr Geiss, and Ms Anderson) and Emory University, Atlanta, Ga (Drs Fantes, Hanna, Thompson, and Waring).


Footnotes



Accepted for publication July 19, 1990.

Reprint requests to Ophthalmology Department, The Eye and Ear Institute of Pittsburgh, 203 Lothrop St, Pittsburgh, PA 15213 (Dr SunderRaj).



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