Healing of excimer laser ablated monkey corneas. An immunohistochemical evaluation
N. SundarRaj, M. J. Geiss 3rd, F. Fantes, K. Hanna, S. C. Anderson, K. P. Thompson, R. A. Thoft and G. O. Waring 3rd
Eye and Ear Institute of Pittsburgh, PA 15213.
The healing response of the cornea following excimer laser anterior
keratomileusis (a 4-mm-diameter ablation to a depth of 11, 23, or 46
microns) was analyzed immunohistochemically in adult rhesus monkeys. The
ablated surface had reepithelialized and the synthesis of type VII collagen
(a major component of anchoring fibrils) was evident by 7 days; the
reestablishment of a nearly continuous anchoring fibril zone was evident
after 12 weeks. Stromal fibroblasts, activated in response to wounding,
expressed a fetal antigen for approximately 6 weeks. Although fibronectin
and type VII collagen were present only transiently in the regenerating
subepithelial stromal matrix in the subepithelial regions, some other
alterations, including the presence of type III collagen, increased levels
of keratan sulfates, and discontinuities in the anchoring fibril zone were
evident even 18 months after wounding. The depths of the regenerated
stroma, which were estimated from the depths of remnant staining for type
VII collagen in the stromal matrix, generally, but not always, corresponded
to the depths of the calculated ablation.
Lornoxicam protects mouse cornea from UVB-induced damage via inhibition of NF-{kappa}B activation
Yin et al.
Br. J. Ophthalmol. 2008;92:562-568.
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Transplantation of Tissue-Engineered Epithelial Cell Sheets after Excimer Laser Photoablation Reduces Postoperative Corneal Haze
Hayashida et al.
IOVS 2006;47:552-557.
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Activation of Matrix Metalloproteinase-8 by Membrane Type 1-MMP and Their Expression in Human Tears after Photorefractive Keratectomy
Holopainen et al.
IOVS 2003;44:2550-2556.
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Detection of Differentially Expressed Genes in Healing Mouse Corneas, Using cDNA Microarrays
Cao et al.
IOVS 2002;43:2897-2904.
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Microarray Analysis of Gene Expression Patterns during Healing of Rat Corneas after Excimer Laser Photorefractive Keratectomy
Varela et al.
IOVS 2002;43:1772-1782.
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Phototherapeutic Keratectomy for Anterior Basement Membrane Dystrophy After Laser In Situ Keratomileusis
Rojas and Manche
Arch Ophthalmol 2002;120:722-727.
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Phototherapeutic keratectomy re-treatment for recurrent corneal erosion syndrome
Maini and Loughnan
Br. J. Ophthalmol. 2002;86:270-272.
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Combined phototherapeutic keratectomy and therapeutic contact lens for recurrent erosions in bullous keratopathy
Lin et al.
Br. J. Ophthalmol. 2001;85:908-911.
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Effects of amniotic membrane on epithelial wound healing and stromal remodelling after excimer laser keratectomy in rabbit cornea
Woo et al.
Br. J. Ophthalmol. 2001;85:345-349.
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Measurement of mRNAs for TGF{beta} and Extracellular Matrix Proteins in Corneas of Rats after PRK
Chen et al.
IOVS 2000;41:4108-4116.
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Plasminogen Activator Activity in Tears after Excimer Laser Photorefractive Keratectomy
Csutak et al.
IOVS 2000;41:3743-3747.
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Confocal microscopy reveals persisting stromal changes after myopic photorefractive keratectomy in zero haze corneas
Böhnke et al.
Br. J. Ophthalmol. 1998;82:1393-1400.
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