This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (77)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Marguerite B. McDonald, MD; Jonathan M. Frantz, MD; Stephen D. Klyce, PhD; Bayardo Salmeron, MD; Roger W. Beuerman, PhD; Charles R. Munnerlyn, PhD; Terrance N. Clapham; Stephen J. Koons, PhD; Herbert E. Kaufman, MD

Arch Ophthalmol. 1990;108(1):40-47.

Abstract
• Photorefractive keratectomy for the correction of myopia was performed in 32 eyes of 16 green monkeys. The corneas healed satisfactorily, with normal formation of basal lamina and hemidesmosomal attachments visible in 14-week histologic specimens. No recurrent erosions were observed clinically. After a transient period of faint haze, all corneas were clear at 17 weeks and remained clear through the 1-year follow-up. In terms of accuracy, all corneas demonstrated a significant flattening compared with preoperative values, but no significant difference was seen between the groups with different intended corrections (1.5 and 3 diopters). The changes in corneal shape stabilized by 17 weeks, as measured by keratometry. The clinical results suggest that mechanical removal of the epithelium is preferable to laser ablation of the epithelium. Overall, the results demonstrate that excimer laser ablation of the corneal stroma can produce a stable dioptric change in the primate cornea with good healing and long-term corneal clarity.

Author Affiliations
From the Lions Eye Research Laboratories, LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.

Footnotes
Accepted for publication September 20,1989.

Reprint requests to LSU Eye Center, 2020 Gravier St, Suite B, New Orleans, LA 70112 (Dr Mc-Donald).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Ten years after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) for moderate to high myopia (control-matched study)
Alio et al.
Br J Ophthalmol 2009;93:1313-1318.
ABSTRACT | FULL TEXT  

Keratocyte Density in the Human Cornea After Photorefractive Keratectomy
Erie et al.
Arch Ophthalmol 2003;121:770-776.
ABSTRACT | FULL TEXT  

Intact corneal epithelium is essential for the prevention of stromal haze after laser assisted in situ keratomileusis
Nakamura et al.
Br J Ophthalmol 2001;85:209-213.
ABSTRACT | FULL TEXT  

Prevention of Keratocyte Loss After Corneal Deepithelialization in Rabbits
Nassaralla et al.
Arch Ophthalmol 1995;113:506-511.
ABSTRACT  

One-Year Results of Excimer Laser Photorefractive Keratectomy for Low to Moderate Myopia
Dutt et al.
Arch Ophthalmol 1994;112:1427-1436.
ABSTRACT  

Quantitative Histological Studies of Primate Corneas After Excimer Laser Photorefractive Keratectomy
Beuerman et al.
Arch Ophthalmol 1994;112:1103-1110.
ABSTRACT  

10 Years: Over 10 000 Manuscripts
Goldberg
Arch Ophthalmol 1994;112:749-751.
ABSTRACT  

Keratocyte Loss After Corneal Deepithelialization in Primates and Rabbits
Campos et al.
Arch Ophthalmol 1994;112:254-260.
ABSTRACT  

The Correction of High Myopia Using the Excimer Laser
Heitzmann et al.
Arch Ophthalmol 1993;111:1627-1634.
ABSTRACT  

Unsuccessful Excimer Laser Phototherapeutic Keratectomy: Clinicopathologic Correlation
McDonnell et al.
Arch Ophthalmol 1992;110:977-979.
ABSTRACT  

Multifocal Corneal Topographic Changes With Excimer Laser Photorefractive Keratectomy
Moreira et al.
Arch Ophthalmol 1992;110:994-999.
ABSTRACT  

A Corneal Flap Technique for Laser In Situ Keratomileusis: Human Studies
Pallikaris et al.
Arch Ophthalmol 1991;109:1699-1702.
ABSTRACT  

The Use of the 193-nm Excimer Laser for Myopic Photorefractive Keratectomy in Sighted Eyes: A Multicenter Study
Sher et al.
Arch Ophthalmol 1991;109:1525-1530.
ABSTRACT  

Photorefractive Keratectomy for Astigmatism: Initial Clinical Results
McDonnell et al.
Arch Ophthalmol 1991;109:1370-1373.
ABSTRACT  

Modulation of Corneal Wound Healing After Excimer Laser Keratomileusis Using Topical Mitomycin C and Steroids
Talamo et al.
Arch Ophthalmol 1991;109:1141-1146.
ABSTRACT  

A Comparative Study of Masking Fluids for Excimer Laser Phototherapeutic Keratectomy
Kornmehl et al.
Arch Ophthalmol 1991;109:860-863.
ABSTRACT  

Photorefractive Keratectomy to Create Toric Ablations for Correction of Astigmatism
McDonnell et al.
Arch Ophthalmol 1991;109:710-713.
ABSTRACT  

Corneal Epithelial and Stromal Reactions to Excimer Laser Photorefractive Keratectomy: I. Concerns Regarding the Response of the Corneal Epithelium to Excimer Laser Ablation
Gipson
Arch Ophthalmol 1990;108:1539-1540.
ABSTRACT  

Corneal Epithelial and Stromal Reactions to Excimer Laser Photorefractive Keratectomy: II. Unpredictable Corneal Cicatrization
Cintron
Arch Ophthalmol 1990;108:1540-1541.
ABSTRACT  

Central Photorefractive Keratectomy for Myopia: The Blind Eye Study
McDonald et al.
Arch Ophthalmol 1990;108:799-808.
ABSTRACT  

Ophthalmology
McDonald
JAMA 1990;263:2668-2669.
ABSTRACT