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Takezo Mito, MD; Takashi Shiono, MD; Sei-ichi Ishiguru, PhD; Makoto Tamai, MD; Katsuyoshi Mizuno, MD; Toshihiro Ohura, MD

Arch Ophthalmol. 1989;107(9):1372-1374.

Abstract
• Gyrate atrophy of the choroid and retina is a rare inherited form of chorioretinal degeneration caused by a deficiency of ornithine aminotransferase. We localized the enzyme in human ocular tissues using immunocytochemical procedures. Immunoreactivity was observed in the nonpigmented epithelium of the ciliary body and lens epithelium. In the retina, ganglion cells and some amacrine cells were immunoreactive. Pigmented granules made it difficult to identify immunoreactive products in the iris, pigmented epithelium of the ciliary body, choroid, and retinal pigment epithelium. Our findings suggested that ornithine aminotransferase plays an important role in ornithine metabolism in these oculartissues.

Author Affiliations
From the Departments of Ophthalmology (Drs Mito, Shiono, Ishiguro, Tamai, and Mizuno) and Pediatrics (Dr Ohura), Tohoku University School of Medicine, Sendai, Japan.

Footnotes
Accepted for publication March 6, 1989.

Reprint requests to Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Miyagi 980, Japan (Dr Mito).

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