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  Vol. 107 No. 8, August 1989 TABLE OF CONTENTS
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Oral acyclovir reduces the incidence of recurrent herpes simplex keratitis in rabbits after penetrating keratoplasty

C. F. Beyer, M. Q. Arens, G. A. Hill, B. T. Rose, L. R. Beyer and D. J. Schanzlin
National Eye Institute, Bethesda, Md.

To determine if acyclovir sodium prevents postoperative herpes simplex virus type 1 (HSV-1) recurrences, 21 rabbits harboring latent HSV-1 underwent uniocular autograft penetrating keratoplasty. All operated-on eyes were treated with topical and subconjunctival dexamethasone sodium phosphate. Ten of the 21 rabbits also received oral acyclovir (intravenous acyclovir was given at the time of surgery). Postoperatively, 9 (82%) of 11 operated-on eyes in rabbits not treated with acyclovir had positive HSV-1 ocular cultures. In acyclovir-treated rabbits, however, none of the 10 operated-on eyes had positive ocular cultures. In addition, 9 (82%) of 11 of the operated-on eyes had geographic ulcers develop in the non-acyclovir-treated rabbits, compared with 1 (10%) of 10 in the acyclovir-treated rabbits. Finally, stromal keratitis appeared in 5 (56%) of 9 of the operated-on eyes in non-acyclovir-treated rabbits and 1 (12%) of 8 of the operated-on eyes in acyclovir-treated rabbits. The results of this study indicate that acyclovir significantly lowered the incidence of HSV-1 ocular shedding, geographic ulceration, and stromal keratitis in a rabbit autograft penetrating keratoplasty model.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Oral Acyclovir After Penetrating Keratoplasty for Herpes Simplex Keratitis
Tambasco et al.
Arch Ophthalmol 1999;117:445-449.
ABSTRACT | FULL TEXT  

Corneal transplantation for herpes simplex keratitis
LARKIN
Br. J. Ophthalmol. 1998;82:107-108.
FULL TEXT  





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