 |
|
Massive Follicular Lymphoid Hyperplasia in Experimental Allergic ConjunctivitisLocal Antibody Production
Mahin Khatami, PhD;
John J. Donnelly, PhD;
Jyoti P. Haldar, PhD;
Zhi-Gang Wei, MD;
John H. Rockey, MD, PhD
Arch Ophthalmol. 1989;107(3):433-438.
Abstract
• Acute and recurrent allergic conjunctival reactions were induced in guinea pigs by repeated conjunctival applications of fluoresceinyl ovalbumin (FL-OA) for up to 30 months. Early type I conjunctival reactions developed 11 to 25 days after the initial conjunctival exposure to FL-OA. Continuous topical challenges during a six- to 30-month period caused a variety of reactions, including papillary changes and massive hyperplasia of the conjunctival-associated lymphoid tissues. Hyperplasia of lymphoid tissues was induced during a shorter period (two to five months) with a mixture of FL-OA and phorbol ester. Culture fluid from hyperplastic conjunctival lymphoid tissue showed a ratio of IgG1/IgG2 antibody production of up to 15. A low level of recurrence of type I reactivity, after an initial desensitization phenomenon due to a loss of reactive mast cells, correlated with prominent follicular hyperplasia of the conjunctival-associated lymphoid tissue.
Author Affiliations
From the Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia.
Footnotes
Accepted for publication Sept 3, 1988.
Reprint requests to Scheie Eye Institute, Myrin Circle, 51 N 39th St, Philadelphia, PA 19104 (Dr Khatami).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Cyclooxygenase Inhibitor Ketorolac or Mast Cell Stabilizers: Immunologic Challenges in Cancer Therapy
Khatami and Mulshine
Clin. Cancer Res. 2005;11:1350-1352.
FULL TEXT
|
