Acetazolamide for treatment of chronic macular edema in retinitis pigmentosa
G. A. Fishman, L. D. Gilbert, R. G. Fiscella, A. E. Kimura and L. M. Jampol
Department of Ophthalmology, University of Illinois, Chicago 60612.
Twelve patients with retinitis pigmentosa and chronic macular edema were
prospectively treated for 2-week periods with acetazolamide or a placebo in
a masked, crossover study. Ten of the 12 patients had both subjective and
objective improvement in visual acuity when treated with acetazolamide.
Improvement was seen even in patients with an acuity as good as 20/25 at
baseline as well as in patients with macular edema present for more than a
decade. A dosage of 500 mg/d was found to be more effective than 250 mg/d.
Six patients (50%) showed lessening of their macular edema on fluorescein
angiography. This angiographically demonstrated improvement was
predominantly due to less detectable leakage from retinal capillaries
rather than from choroidal capillaries through the retinal pigment
epithelium. Improvement in visual acuity was seen in some patients without
a detectable change in the amount of angiographic fluorescein leakage.
The prevalence of cystoid macular oedema in retinitis pigmentosa patients determined by optical coherence tomography
Hajali et al.
Br. J. Ophthalmol. 2008;92:1065-1068.
ABSTRACT
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Treatment of Cystoid Macular Edema in Retinitis Pigmentosa With Intravitreal Triamcinolone
Scorolli et al.
Arch Ophthalmol 2007;125:759-764.
ABSTRACT
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Continued use of dorzolamide for the treatment of cystoid macular oedema in patients with retinitis pigmentosa
Fishman and Apushkin
Br. J. Ophthalmol. 2007;91:743-745.
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The Retinal Pigment Epithelium in Visual Function
Strauss
Physiol. Rev. 2005;85:845-881.
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Disease Expression in Usher Syndrome Caused by VLGR1 Gene Mutation (USH2C) and Comparison with USH2A Phenotype
Schwartz et al.
IOVS 2005;46:734-743.
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Outcome of cataract surgery in patients with retinitis pigmentosa
Jackson et al.
Br. J. Ophthalmol. 2001;85:936-938.
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Effects of Acetazolamide on Passive and Active Transport of Fluorescein across the Normal BRB
Moldow et al.
IOVS 1999;40:1770-1775.
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Electrophysiological evaluation of visual loss in Muller cell sheen dystrophy
Kellner et al.
Br. J. Ophthalmol. 1998;82:650-654.
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