 |
|
Pathogenesis of Epidemic Dropsy Glaucoma
Mahipal S. Sachdev, MD;
N. N. Sood, FRCS;
Lalit K. Verma, MD;
S. K. Gupta, PhD;
Nargis F. Jaffery, PhD
Arch Ophthalmol. 1988;106(9):1221-1223.
Abstract
• Thirty-one cases of epidemic dropsy with raised intraocular pressure were studied. Glaucoma was bilateral in all, with open angles and no signs of anterior segment inflammation. The outflow facility was unimpaired (C value, 0.24 ± 0.09 µL/min/mm Hg). Aqueous bioassays revealed significantly elevated prostaglandin E2 level (23.33 ± 4.32 ng/mL) and histamine activity (13.0 ± 2.76 ng/ mL) in all samples from patients with epidemic dropsy glaucoma as compared with negligible levels in control samples from patients with open angle glaucoma. Aqueous biochemical analysis revealed increased total protein level (1.03 ± 0.10 g/L) with a normal globulin pattern as compared with controls (0.26 ± 0.08 g/ L). On histopathologic and histochemical testing, a normal trabecular meshwork was found in 11 of the 12 trabeculectomy specimens. It is concluded that dropsy glaucoma is hypersecretory in nature; prostaglandin and histamine release may have significant roles in its pathogenesis.
Author Affiliations
From the Department of Ophthalmology (Drs Sachdev, Sood, and Verma), Ocular Pharmacology Section (Dr Gupta), and Ocular Biochemistry Section (Dr Jaffery), Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.
Footnotes
Accepted for publication April 12, 1988.
Reprint requests to Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India (Dr Sachdev).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Classic diseases revisited: Epidemic dropsy in India
Sharma et al.
Postgrad. Med. J. 1999;75:657-661.
ABSTRACT
| FULL TEXT
|
