 |
|
Prostaglandin-Independent Inhibition of Ocular Vascular Permeability by a Platelet-Activating Factor Antagonist
Richard M. Rubin, MD;
John R. Samples, MD;
James T. Rosenbaum, MD
Arch Ophthalmol. 1988;106(8):1116-1120.
Abstract
| |
• Platelet-activating factor (PAF), a lipid mediator of inflammation, may markedly increase vascular permeability. We assessed the ability of the PAF antagonist SRI 63-441 to inhibit ocular vascular permeability induced by the intravenous injection of endotoxin or anterior chamber paracentesis. The PAF antagonist SRI 63-441 significantly blocked ocular vascular permeability following either intravenous endotoxin or anterior chamber paracentesis as determined by the reduction in accumulation of 70 000-molecularweight fluorescein isothiocyanate—conjugated dextran or serum proteins into the anterior chamber. SRI 63-441 did not reduce increases in aqueous humor prostaglandin E2 levels. The efficacy of the PAF antagonist was additive in combination with either topical indomethacin or topical corticosteroid. Combined therapy almost completely prevented increases in ocular vascular permeability. These data support the conclusion that multiple mediators contribute to ocular vascular permeability and that combinations of pharmacologic agents may be superior to a single drug.
Author Affiliations
From the Oregon Health Sciences University, Portland.
Footnotes
Accepted for publication Feb 1, 1988.
Reprint requests to Oregon Health Sciences University, Mail Code L329A, 3181 Sam Jackson Park Rd SW, Portland, OR 97201 (Dr Rosenbaum).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Synthesis of Platelet Activating Factor by Ocular Tissue From Inflamed Eyes
Rosenbaum et al.
Arch Ophthalmol 1991;109:410-413.
ABSTRACT
|
