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Bilateral Cavernous Sinus Thrombosis due to Mucormycosis
E. Van Johnson, MD;
Lanning B. Kline, MD;
Bruce A. Julian, MD;
Julio H. Garcia, MD
Arch Ophthalmol. 1988;106(8):1089-1092.
Abstract
A 49-year-old man requiring hemodialysis for end-stage renal disease developed orbital cellulitis and bilateral central retinal artery occlusions. Although cranial computed tomography demonstrated ethmoid and sphenoid sinusitis, two surgical biopsy specimens of sinus mucosa were nondiagnostic. Autopsy findings confirmed cerebral mucormycosis with bilateral cavernous sinus and carotid artery thrombosis. The patient had been taking deferoxamine for hemochromatosis, and this chelating agent may have been the predisposing factor in developing mucormycosis. We discuss the limitations of current neuroimaging techniques in establishing the diagnosis of both cerebral mucormycosis and cavernous sinus thrombosis.
Author Affiliations
From the Combined Program in Ophthalmology, Eye Foundation Hospital (Drs Johnson and Kline), and the Departments of Medicine (Dr Julian) and Pathology (Dr Garcia), University of Alabama School of Medicine, Birmingham.
Footnotes
Accepted for publication March 28, 1988.
Reprint requests to Suite 555, 1600 Seventh Ave S, Birmingham, AL 35233 (Dr Kline).
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