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Dexamethasone Inhibition of Phagocytosis by Corneal Keratocytes in Culture
Hiroshi Mishima, MD, DSc;
Teruo Nishida, MD, DSc;
Toshifumi Otori, MD, DSc
Arch Ophthalmol. 1988;106(7):978-980.
Abstract
• To investigate the effect of steroid hormone on phagocytosis by keratocytes, we investigated the phagocytic activities for latex beads by rabbit corneal keratocytes cultured in the presence and absence of dexamethasone. Culturing the corneal keratocytes with dexamethasone inhibited the phagocytic activity for latex beads in a dose-dependent fashion. The inhibitory effects depended on the duration of the incubation period of the cells with dexamethasone.
Author Affiliations
From the Department of Ophthalmology, Kinki University School of Medicine, Osaka, Japan.
Footnotes
Accepted for publication Feb 19, 1988.
Read in part before the Japanese chapter of the International Society of Eye Research, Sendai, Japan, Nov 30, 1985.
Reprint requests to Department of Ophthalmology, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka-Sayama City, Osaka 589, Japan (Dr Mishima).
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