Acute posterior multifocal placoid pigment epitheliopathy and cerebral vasculitis
C. A. Wilson, E. A. Choromokos and R. Sheppard
Department of Ophthalmology, University of Cincinnati College of Medicine, OH.
Four cases of suspected cerebral vasculitis have been described in
association with acute posterior multifocal placoid pigment epitheliopathy,
but none was confirmed histopathologically. We describe a patient who
developed fatal cerebral vasculitis after placoid pigment epitheliopathy.
Histopathologic data revealed a focal granulomatous inflammation of
medium-sized arteries in the leptomeninges. Multinucleated giant cells were
a conspicuous part of the inflammatory reaction. The cause of both placoid
pigment epitheliopathy and cerebral vasculitis remains obscure.
