Penetration of topically applied dexamethasone alcohol into human aqueous humor

doi:10.1001/archopht.106.5.686

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Vol. 106 No. 5, May 1988

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Penetration of topically applied dexamethasone alcohol into human aqueous humor

D. Watson, M. J. Noble, G. N. Dutton, J. M. Midgley and T. M. Healey
Department of Pharmacy, University of Strathclyde, Glasgow, Scotland.

Gas chromatography combined with mass spectrometry was used to determine the absorption of topically applied dexamethasone alcohol into the aqueous humor of human subjects undergoing routine intraocular surgery. The dexamethasone concentration in aqueous humor was greatest in the interval between 91 and 120 minutes following instillation (mean concentration, 31 ng/mL). Dexamethasone was still detectable in the aqueous 12 hours after instillation.

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