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Photothrombosis of Corneal Neovascularization by Intravenous Rose Bengal and Argon Laser Irradiation
Andrew J. W. Huang, MD, MPH;
Brant D. Watson, PhD;
Eleut Hernandez;
Scheffer C. G. Tseng, MD, PhD
Arch Ophthalmol. 1988;106(5):680-685.
Abstract
• Management of corneal neovascularization by photocoagulation has been limited and rarely successful. We evaluated the efficacy and safety of the novel technique of photothrombosis to occlude corneal neovascularization. Sixteen rabbit corneas with previous ocular surface wounds that had healed with 360° extensive neovascularization (persistent for 20 months) were used. After an intravenous injection of rose bengal solution (40 mg/ kg of body weight [BW]), each vessel on the upper half of the cornea was occluded with a photochemically induced thrombus within ten shots of argon laser irradiation (514.5 nm, 130 mW, 63 µm, 0.2 s); those on the lower half were used as an internal control. Throughout the four-month study period, the treated vessels remained occluded, as evidenced by corneal fluorescein angiography. Corneal clarity was improved after treatment. A single injection of rose bengal at a dose of 8 mg/kg of BW or higher was sufficient for successful photothrombotic occlusion of corneal vessels within one hour of experimentation. Transient elevations of serum urea nitrogen, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total bilirubin levels and decrease of serum phosphorus level were noted on the first day after injection with 40 mg/kg of BW of rose bengal solution.
Author Affiliations
From the Department of Ophthalmology, Bascom Palmer Eye Institute (Drs Huang, Hernandez, and Tseng), and the Cerebral Vascular Disease Research Center, Department of Neurology (Dr Watson), University of Miami School of Medicine.
Footnotes
Accepted for publication Nov 23, 1987.
Presented in part at the Seventh Annual Meeting of the American Society for Laser Medicine and Surgery, San Francisco, April 11-13, 1987, and at the Annual Association for Research in Vision and Ophthalmology Meeting, Sarasota, Fla, May 4-8, 1987.
Reprint requests to the Bascom Palmer Eye Institute, PO Box 016880, Miami, FL 33101 (Dr Tseng).
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