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Suppression of Experimental Tractional Retinal Detachment by Low-Dose Radiation Therapy
Travis A. Meredith, MD;
Linda Ficker, FRCS;
Rosalind Stevens, MD;
Zbigniew Olkowski, MD;
Marjorie Anderson;
Janet Hartmann;
Ian Crocker, MD
Arch Ophthalmol. 1988;106(5):673-675.
Abstract
• We used a standardized model of traction retinal detachment (TRD) created by cellular membranes in the rabbit to test the effects of low-dose radiation therapy in suppressing TRD. The vitreous and lens were removed from pigmented rabbits, and homologous conjunctival fibroblasts were grown in cell culture. After resolution of postoperative inflammation, 50 000 fibroblasts in 0.1 mL of culture fluid were injected into the vitreous cavity. Ten eyes were maintained as controls. Nineteen eyes received 6 Gy (600 rad) of x-ray irradiation one to three hours after cellular injection. Eyes were monitored weekly for three weeks with indirect ophthalmoscopy. Seven (70%) of ten control eyes developed TRD at one week; no additional TRDs were noted at weeks 2 and 3. Significantly smaller numbers of irradiated eyes developed TRD: at week 1, two (11%) of 19; at week 2, five (28%) of 18; and at week 3, five (29%) of 17.
Author Affiliations
From the Departments of Ophthalmology (Drs Meredith, Flicker, and Stevens, and Mss Anderson and Hartmann) and Radiology (Drs Olkowski and Crocker), Emory University, Atlanta.
Footnotes
Accepted for publication Dec 30, 1988.
Read in part at the Association for Research in Vision and Ophthalmology meeting, Sarasota, Fla, May 7, 1987.
Reprint requests to Department of Ophthalmology, Emory University Eye Center, 1327 Clifton Rd NE, Atlanta, GA 30322 (Dr Meredith).
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