Vitamin D and retinoblastoma. The presence of receptors and inhibition of growth in vitro
A. M. Saulenas, S. M. Cohen, L. L. Key, C. Winter and D. M. Albert
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114.
The vitamin D receptor has been found in several human organs not involved
in calcium metabolism and in several malignant neoplasms found in humans.
The role of the receptor in these tissues is unclear. There is, however, a
relationship between the presence and quantity of the vitamin D receptor in
a malignant cell line and the antineoplastic effect of vitamin D on that
cell line. We found that Y-79 retinoblastoma cells have receptors specific
for calcitriol (1,25-dihydroxycholecalciferol). Scatchard analysis of the
receptor data shows a quantity of 56,000 receptors per retinoblastoma cell.
These receptors have a dissociation constant of 1.18 nmol/L. Retinoblastoma
cells treated with 10(-9) mol/L of calcitriol for nine days had 15% less
cell growth than the control cells. Further studies of the effect of
vitamin D on retinoblastoma may warrant its inclusion in chemotherapeutic
protocols for the treatment of this childhood affliction.
Association between a Protein Polymorphism in the Start Codon of the Vitamin D Receptor Gene and Severe Diabetic Retinopathy in C-Peptide-Negative Type 1 Diabetes
Taverna et al.
J. Clin. Endocrinol. Metab. 2005;90:4803-4808.
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Effectiveness of Vitamin D Analogues in Treating Large Tumors and During Prolonged Use in Murine Retinoblastoma Models
Albert et al.
Arch Ophthalmol 2004;122:1357-1362.
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Effectiveness of 1{alpha}-Hydroxyvitamin D2 in Inhibiting Tumor Growth in a Murine Transgenic Pigmented Ocular Tumor Model
Albert et al.
Arch Ophthalmol 2004;122:1365-1369.
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Vitamin D Analogues Increase p53, p21, and Apoptosis in a Xenograft Model of Human Retinoblastoma
Audo et al.
IOVS 2003;44:4192-4199.
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Toxicity and Dose-Response Studies of 1{alpha}-Hydroxyvitamin D2 in a Retinoblastoma Xenograft Model
Grostern et al.
Arch Ophthalmol 2002;120:607-612.
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Antineoplastic Effect and Toxicity of 1,25-Dihydroxy-16-ene-23-yne-vitamin D3 in Athymic Mice With Y-79 Human Retinoblastoma Tumors
Sabet et al.
Arch Ophthalmol 1999;117:365-370.
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