Quantitative assessment of postsurgical breakdown of the blood-aqueous barrier following administration of 0.5% ketorolac tromethamine solution. A double-masked, paired comparison with vehicle-placebo solution study
A. J. Flach, J. Graham, L. P. Kruger, R. C. Stegman and L. Tanenbaum
Department of Ophthalmology, University of California, San Francisco.
Preoperative and serial postoperative anterior chamber fluorophotometry
were performed after oral administration of fluorescein sodium in patients
undergoing extracapsular cataract extraction and posterior chamber
intraocular lens insertion. The administration of topical 0.5% ketorolac
tromethamine solution before and after surgery markedly decreased the
breakdown of the blood-aqueous barrier compared with vehicle-placebo
solution administration at each time period, as measured by
fluorophotometry. Corticosteroids were not given to any patients throughout
the duration of the study. These fluorophotometric results correlated well
with slit-lamp observations of postoperative ocular inflammation. Both
ketorolac and vehicle were well tolerated by patients. No effects on
intraocular pressure were seen with ketorolac administration. This study
suggests that ketorolac ophthalmic solution is effective and safe as a
nonsteroidal anti-inflammatory agent for topical use following cataract
surgery and intraocular lens implantation.
