Methicillin-resistant Staphylococcus epidermidis keratitis treated with vancomycin
D. F. Goodman and J. D. Gottsch
Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21205.
Staphylococcus epidermidis accounts for nearly one third of all cases of
bacterial keratitis in certain geographic areas. Recently, the sensitivity
of this organism has changed dramatically so that nearly half of
nosocomially acquired systemic S epidermidis infections are resistant to
methicillin sodium, cephalosporins, and aminoglycosides.
Methicillin-resistant and gentamicin sulfate-resistant S epidermidis
causing infectious blepharoconjunctivitis and endophthalmitis has
previously been reported. Two cases of methicillin- and
gentamicin-resistant S epidermidis keratitis occurred that were treated
successfully with topical vancomycin hydrochloride.
