Natural course of poorly defined choroidal neovascularization associated with macular degeneration
N. M. Bressler, L. A. Frost, S. B. Bressler, R. P. Murphy and S. L. Fine
Retinal Vascular Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
We obtained follow-up data on 84 eyes with age-related macular degeneration
and poorly defined angiographic leakage presumed to represent choroidal
neovascularization. A poorly defined neovascular membrane was presumed to
be present when subsensory retinal fluid was present in association with
choroidal leakage on fluorescein angiography and in which the extent of
leakage was not well defined. Among the 84 eyes, the average initial visual
acuity was 20/80. In 75 (89%) of 84 eyes, the leakage involved the foveal
center at initial presentation. At follow-up (average, 28 months; range,
six to 53 months), the average visual acuity was 20/250; the final acuity
declined at least three but less than six lines in 18 eyes (21%) and six or
more lines in 35 eyes (42%). There was a statistically significant
difference in the percentage of eyes that developed moderate or severe
visual loss among eyes that progressed to disciform scarring compared with
eyes that continued to manifest poorly defined leakage without evidence of
scarring. Given that most severe visual loss associated with macular
degeneration can be attributed to consequences of neovascular membranes and
that many membranes associated with age-related macular degeneration are
poorly defined, our study results support the possibility that poorly
defined neovascular membranes represent a major cause of severe visual loss
among the elderly in the United States.
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Choroidal neovascularisation and atrophy.
Sunness
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Long term results after transpupillary thermotherapy in eyes with occult choroidal neovascularisation associated with age related macular degeneration: a prospective trial
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Clinicopathologic Correlation of Progressive Fibrovascular Proliferation Associated With Occult Choroidal Neovascularization in Age-Related Macular Degeneration
Csaky et al.
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Finger et al.
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Br. J. Ophthalmol. 2001;85:184-188.
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Long term results of radiotherapy for subfoveal choroidal neovascularisation in age related macular degeneration
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Radiotherapy for isolated occult subfoveal neovascularisation in age related macular degeneration: a pilot study
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Br. J. Ophthalmol. 1999;83:646-651.
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Indocyanine green angiographic features prognostic of visual outcome in the natural course of patients with age related macular degeneration
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Br. J. Ophthalmol. 1999;83:429-437.
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