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Retinal Pigment Epithelial Cells in Culture Produce Retinal Vascular Mitogens
Hong Chai Wong, FRCS;
Mike Boulton, PhD;
David McLeod, FRCS;
Meryl Bayly;
Peter Clark, MSc;
John Marshall, PhD
Arch Ophthalmol. 1988;106(10):1439-1443.
Abstract
• Conditioned medium from human retinal pigment epithelial cells in culture significantly stimulated the proliferation of subcultured bovine retinal capillary endothelial cells, pericytes, and freshly isolated retinal microvessels. The vascular mitogenic activity enhanced that of retinal crude extract. No evidence emerged of an inhibitor of microvascular cellular proliferation produced by retinal pigment epithelial cells.
Author Affiliations
From the Surgical Vitreoretinal Unit, Moorfields Eye Hospital (Drs Wong and McLeod), and the Department of Clinical Ophthalmology, Institute of Ophthalmology (Drs Boulton and Marshall, Ms Bayly, and Mr Clark), London.
Footnotes
Accepted for publication June 16, 1988.
Reprint requests to Institute of Ophthalmology, Judd Street, London WCIH 9QS, United Kingdom (Dr Boulton).
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