Corneal toxicity of propamidine
K. J. Johns, W. S. Head and D. M. O'Day
Department of Ophthalmology, Vanderbilt University Medical Center, Nashville, TN 37232.
Two patients with Acanthamoeba keratitis developed a corneal abnormality
following prolonged treatment with topical 0.1% [corrected] propamidine
isethionate. In both instances, withdrawal of drug therapy resulted in a
gradual clearing of the keratopathy, with no permanent sequelae. The
changes we observed may be confused with those of active Acanthamoeba
infection.
