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  Vol. 105 No. 8, August 1987 TABLE OF CONTENTS
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Pilocarpine Antagonizes Prostaglandin F2{alpha}-Induced Ocular Hypotension in Monkeys

Evidence for Enhancement of Uveoscleral Outflow by Prostaglandin F2{alpha}

Kathryn Crawford; Paul L. Kaufman, MD

Arch Ophthalmol. 1987;105(8):1112-1116.


Abstract

• Twice daily topical application of 50 µg of prostaglandin F2{alpha} tromethamine to cynomolgus monkey eyes produced significant ocular hypotension lasting at least six hours, with the intraocular pressure (IOP) falling between 35% and 50%, ie, to about 8 to 10 mm Hg, following the seventh dose. A single topical application of 1 mg of pilocarpine hydrochloride produced a much smaller IOP reduction and strong, probably maximal accommodation, both of which lasted at least eight hours. When prostaglandin F2{alpha}-treated eyes were given pilocarpine before the seventh dose of prostaglandin F2{alpha}, accommodation and IOP responded as in eyes receiving pilocarpine only. Atropine sulfate pretreatment of eyes receiving pilocarpine and prostaglandin F2{alpha} completely prevented pilocarpine-induced accommodation and inhibition of ocular hypotension induced by prostaglandin F2{alpha}. We hypothesize that (1) prostaglandin F2{alpha} reduces IOP by increasing uveoscleral drainage of aqueous humor, and (2) pilocarpine pretreatment contracts the ciliary muscle, obliterating the intramuscular spaces and closing off the uveoscleral drainage pathway and thus physiologically blocking the effect.



Author Affiliations

From the Department of Ophthalmology, University of Wisconsin Medical School, Madison.


Footnotes

Accepted for publication March 17, 1987.

Reprint requests to Department of Ophthalmology, University of Wisconsin Clinical Sciences Center, 600 Highland Ave, Madison, WI 53792 (Dr Kaufman).



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