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Pilocarpine Antagonizes Prostaglandin F2-Induced Ocular Hypotension in Monkeys

Evidence for Enhancement of Uveoscleral Outflow by Prostaglandin F2

Kathryn Crawford; Paul L. Kaufman, MD

Arch Ophthalmol. 1987;105(8):1112-1116.

Abstract
• Twice daily topical application of 50 µg of prostaglandin F₂ tromethamine to cynomolgus monkey eyes produced significant ocular hypotension lasting at least six hours, with the intraocular pressure (IOP) falling between 35% and 50%, ie, to about 8 to 10 mm Hg, following the seventh dose. A single topical application of 1 mg of pilocarpine hydrochloride produced a much smaller IOP reduction and strong, probably maximal accommodation, both of which lasted at least eight hours. When prostaglandin F₂-treated eyes were given pilocarpine before the seventh dose of prostaglandin F₂, accommodation and IOP responded as in eyes receiving pilocarpine only. Atropine sulfate pretreatment of eyes receiving pilocarpine and prostaglandin F₂ completely prevented pilocarpine-induced accommodation and inhibition of ocular hypotension induced by prostaglandin F₂. We hypothesize that (1) prostaglandin F₂ reduces IOP by increasing uveoscleral drainage of aqueous humor, and (2) pilocarpine pretreatment contracts the ciliary muscle, obliterating the intramuscular spaces and closing off the uveoscleral drainage pathway and thus physiologically blocking the effect.

Author Affiliations
From the Department of Ophthalmology, University of Wisconsin Medical School, Madison.

Footnotes
Accepted for publication March 17, 1987.

Reprint requests to Department of Ophthalmology, University of Wisconsin Clinical Sciences Center, 600 Highland Ave, Madison, WI 53792 (Dr Kaufman).

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