 |
|
Topical vs Systemic Gentamicin Penetration Into the Human Cornea and Aqueous Humor
Michael S. Insler, MD;
Craig J. Helm;
William J. George, PhD
Arch Ophthalmol. 1987;105(7):922-924.
Abstract
• Twenty-two patients undergoing penetrating keratoplasty received either topical fortified gentamicin (13.6 mg/mL) or a loading dose of intramuscular gentamicin before surgery. Cornea and aqueous humor samples were obtained and assayed by radioimmunoassy for gentamicin. In the topical group, the average gentamicin levels in the cornea and aqueous were 16.2 µg/g and 0.3 µg/mL, respectively. Parenteral drug levels were less variable and averaged 6.1 µg/g in the cornea and 0.4 µg/mL in the aqueous. Although this study demonstrates that parenteral therapy can be used to deliver adequate drug levels to the cornea, it requires far more antibiotic and subjects the patient to potentially toxic systemic side effects. Therefore, topical administration is the preferred route of delivery of antibiotic to the cornea.
Author Affiliations
From the LSU Eye Center, Louisiana State University Medical Center School of Medicine (Dr Insler); and the Departments of Ophthalmology (Mr Helm) and Pharmacology (Dr George), Tulane University Medical School, New Orleans.
Footnotes
Accepted for publication Feb 11, 1987.
Reprint requests to LSU Eye Center, 2020 Gravier St, Suite B, New Orleans, LA 70112 (Dr Insler).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Delivery of Gentamicin to the Rabbit Eye by Drug-Loaded Hydrogel Iontophoresis
Eljarrat-Binstock et al.
IOVS 2004;45:2543-2548.
ABSTRACT
| FULL TEXT
Human corneal stromal tissue concentration after consecutive doses of topically applied 3.3% vancomycin
Cahane et al.
Br J Ophthalmol 2004;88:22-24.
ABSTRACT
| FULL TEXT
Collagen-Shield Delivery of Gentamicin and Vancomycin
Phinney et al.
Arch Ophthalmol 1988;106:1599-1604.
ABSTRACT
|
