Metoclopramide as prophylaxis for nausea and vomiting induced by fluorescein
R. E. Brown Jr, R. Sabates and S. J. Drew
Fluorescein angiography carries with it a variable incidence of nausea and
vomiting. We investigated a method of prophylaxis against this side effect.
One hundred patients undergoing fluorescein angiography were pretreated in
a double-masked, randomized fashion with either 20 mg of intravenous
metoclopramide hydrochloride or an equal volume of normal saline solution.
The metoclopramide-treated group demonstrated a statistically significant
decrease in the incidence of nausea and vomiting. Eleven (22%) of the
control group and three (6%) of the metoclopramide-treated group had this
complication. Metoclopramide is an effective drug when used
prophylactically in selected patients undergoing fluorescein angiography.