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Shmuel Levinger, MD; Hanan Zauberman, MD; Amiram Eldor, MD; Arieh Zelikovitch; Eliezer Rosenmann, MD

Arch Ophthalmol. 1987;105(4):554-558.

Abstract
• The thrombolytic effect of urokinase was tested on cat retinal vein thrombus induced by argon laser photocoagulation. At various time intervals after thrombosis, intravenous infusion or subconjunctival injections were given. Subconjunctival normal saline injections were used for controls. In vitro subconjunctival urokinase prevented thrombus organization if given within six hours of thrombosis. Subconjunctival injections of urokinase vs normal saline were also studied in vivo in a masked fashion. At intervals of three to 24 hours following thrombosis, 11 cats were treated with subconjunctival urokinase in one eye and normal saline in the 11 fellow eyes. Within ten days after thrombosis, the vein was patent in eight (72%) of the 11 eyes treated with urokinase and in one (9%) of the 11 control eyes.

Author Affiliations
From the Departments of Ophthalmology (Drs Levinger and Zauberman and Mr Zelikovitch), Hematology (Dr Eldor), and Pathology (Dr Rosenmann), Hadassah University Hospital and Hebrew University Medical School, Jerusalem.

Footnotes
Accepted for publication June 2, 1986.

The authors have no commercial, proprietary, or financial interest in any equipment, instrument, or drug discussed in this study.

Reprint requests to Department of Ophthalmology, Hadassah University Hospital, PO Box 12000, 91120 Jerusalem, Israel (Dr Zauberman).

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