This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (16)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Bartly J. Mondino, MD; Andrew I. Caster, MD; Brent Dethlefs

Arch Ophthalmol. 1987;105(3):409-412.

Abstract
• Rabbits immunized with cell wall antigens of Staphylococcus aureus developed blepharitis after topical challenge with viable S aureus. The lids of these rabbits were thickened and erythematous. Crusting was found around the lashes, and the lids developed loss of lashes and hair. Histopathologic examination of lids from rabbits with blepharitis showed a dense leukocytic infiltrate and dilated blood vessels beneath an intact epidermis and palpebral conjunctival epithelium. The infiltrate contained neutrophils as well as mononuclear cells, including macrophages, plasma cells, and lymphocytes. The meibomian glands appeared normal. Gram's staining of lid sections did not show gram-positive cocci. The results of this study suggest that hypersensitivity to the S aureus cell wall, and particularly the ribitol teichoic acid that it contains, plays a role in the pathogenesis of staphylococcal blepharitis.

Author Affiliations
From the Department of Ophthalmology, Jules Stein Eye Institute, UCLA School of Medicine.

Footnotes
Accepted for publication July 21, 1986.

Reprint requests to Department of Ophthalmology, Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA 90024 (Dr Mondino).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pathogenesis of Gram-Positive Bacterial Endophthalmitis
Callegan et al.
Infect. Immun. 1999;67:3348-3356.
ABSTRACT | FULL TEXT