This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

John A. Seedor, MD; Henry D. Perry, MD; Thomas F. McNamara, PhD; Lorne M. Golub, DMD; Douglas F. Buxton, MD; Debra S. Guthrie, MD

Arch Ophthalmol. 1987;105(2):268-271.

Abstract
• Recent evidence has demonstrated a marked anticollagenolytic effect for the tetracycline antibiotics. We have examined the efficacy of systemic tetracycline hydrochloride in a rabbit model of corneal ulceration. A standard alkali burn (1N sodium hydroxide for 40 s) was delivered to 62 eyes (31 rabbits). Animals were then divided into three groups: group 1 (controls) (ten rabbits [20 eyes]) received no treatment; group 2 (ten rabbits [20 eyes]) received 10 mg/kg/d of tetracycline hydrochloride, given intramuscularly; and group 3 (11 rabbits [22 eyes]) received 50 mg/kg/d. Ulceration occurred in 85% (17/20) of control eyes. The higher dosage of tetracycline was more effective in preventing ulceration than the lower dosage (9.1% vs 55%). Eyes with higher levels of tetracycline in ocular tissues were less likely to ulcerate.

Author Affiliations
From the Department of Ophthalmology, New York Eye and Ear Infirmary, New York (Drs Seedor, Perry, Buxton, and Guthrie), and the Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook (Drs McNamara and Golub).

Footnotes
Accepted for publication June 6, 1986.

Reprint requests to 2000 N Village Ave, Rockville Centre, NY (Dr Perry).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Temporary Sutureless Amniotic Membrane Patch for Acute Alkaline Burns
Kheirkhah et al.
Arch Ophthalmol 2008;126:1059-1066.
ABSTRACT | FULL TEXT  

Doxycycline Inhibits TGF-{beta}1-Induced MMP-9 via Smad and MAPK Pathways in Human Corneal Epithelial Cells
Kim et al.
IOVS 2005;46:840-848.
ABSTRACT | FULL TEXT  

Regulated Expression of Collagenases MMP-1, -8, and -13 and Stromelysins MMP-3, -10, and -11 by Human Corneal Epithelial Cells
Li et al.
IOVS 2003;44:2928-2936.
ABSTRACT | FULL TEXT  

Failure of amniotic membrane transplantation in the treatment of acute ocular burns
Joseph et al.
Br J Ophthalmol 2001;85:1065-1069.
ABSTRACT | FULL TEXT  

Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms
Golub et al.
ADR 1998;12:12-26.
ABSTRACT