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John H. K. Liu, PhD; Angela C. Dacus

Arch Ophthalmol. 1987;105(2):245-248.

Abstract

• Systemic administration of cannabinoids decreases intraocular pressure (IOP). To determine whether the mechanism of action originates in the central nervous system, we administered various cannabinoids into the cerebral ventricles of conscious New Zealand albino rabbits. When ⁹-tetrahydrocannabinol (⁹-THC), ⁸-tetrahydrocannabinol, cannabinol, and cannabidiol were given intravenously, only ⁹-THC produced dose-dependent ocular hypotension and miosis. Bolus administration into the cerebral ventricles or ventriculocisternal perfusion of ⁹-THC did not change IOP or pupil size. In urethane-anesthetized rabbits, IOP and blood pressure were lowered by intravenous administration of ⁹-THC but not by bolus cerebral administration. These observations indicate that the action of cannabinoids on IOP does not originate in the central nervous system. Alteration of blood pressure may be involved in the mechanism of ocular hypotension induced by ⁹-THC.

Author Affiliations

Footnotes

Read in part before the Annual Meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 2, 1986.

Reprint requests to Eye Research Institute of Retina Foundation, 20 Staniford St, Boston, MA 02114 (Dr Liu).

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