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Paul A. Blacharski, MD; Steven T. Charles, MD

Arch Ophthalmol. 1987;105(2):203-205.

Abstract
• We prospectively studied 36 consecutive premature infants with the diagnosis of retinopathy of prematurity stage V with total traction retinal detachment who underwent lensectomy/vitrectomy and epiretinal membrane delamination. The first 26 patients underwent vitrectomy using thrombin mixed with Balanced Salt Solution Plus at a concentration of 100 U/ mL and the remaining ten patients had pure Balanced Salt Solution Plus used. Intraoperative and postoperative bleeding were monitored. The overall intraoperative bleeding rate was 92% (33/36). Intraoperative bleeding (19% vs 80%) and bleeding at the time of wound closure (4% vs 30%) were both significantly reduced in the thrombin vs no thrombin group.

Author Affiliations
From the University of Tennessee Medical Center, Memphis.

Footnotes
Accepted for publication July 9, 1986.

Reprint requests to 6401 Poplar Ave, Suite 190, Memphis, TN 38119 (Dr Charles).

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