 |
|
Retinal Cryopexy Stimulates Traction Retinal Detachment Formation in the Presence of an Ocular Wound
Peter A. Campochiaro, MD;
Hugh C. Gaskin, MD;
Stanley A. Vinores, PhD
Arch Ophthalmol. 1987;105(11):1567-1570.
Abstract
| |
• Pigmented rabbits were treated with retinal cryopexy applied to 180° of the peripheral inferior retina in one eye, and then a 6-mm full-thickness circumferential wound was made in both eyes 3 mm posterior to the superior limbus. The wounds were sutured, and only eyes with minimal vitreous hemorrhage and no retinal breaks were included in the study. Eyes were then examined with indirect ophthalmoscopy on postoperative days 1, 7, 14, 21, and 28. Of eyes that received cryopexy and an ocular wound (n = 13), the retina in three became totally detached between postoperative days 14 and 28; seven eyes had traction retinal detachment first noted on postoperative day 14 that did not become total by postoperative day 28; and two retinas remained attached, but showed folds suggesting the presence of epiretinal membranes. One retina remained attached without folding. In eyes that received only an ocular wound (n = 13), the retina in one showed folds, and in 12 eyes it remained attached with no evidence of epiretinal membrane formation. Retinas treated with cryopexy alone (n = 4) remained attached without folds. On postoperative day 28, the rabbits were killed, and, after fixation, eyes were examined grossly and by light and electron microscopy. Examination confirmed the presence of vitreous and epiretinal cellular membranes in eyes with retinal detachment. These data suggest that in the presence of an ocular wound, retinal cryopexy, which has previously been shown to cause extensive breakdown of the blood-retinal barrier, stimulates the formation of intraocular cellular membranes and traction retinal detachment.
Author Affiliations
From the Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville.
Footnotes
Accepted for publication July 14, 1987.
Read in part before the Spring Meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 7, 1987.
Reprint requests to Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908 (Dr Campochiaro).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Photoreceptor-Specific Expression of Platelet-Derived Growth Factor-B Results in Traction Retinal Detachment
Seo et al.
Am. J. Pathol. 2000;157:995-1005.
ABSTRACT
| FULL TEXT
Globe perforation during botulinum toxin injection
MOHAN and FLECK
Br J Ophthalmol 1999;83:501d-501.
FULL TEXT
Hyalocytes Synthesize and Secrete Inhibitors of Retinal Pigment Epithelial Cell Proliferation In Vitro
Lazarus et al.
Arch Ophthalmol 1996;114:731-736.
ABSTRACT
2Peripheral Scatter Photocoagulation for Neovascularization Associated With Pars Planitis
Park et al.
Arch Ophthalmol 1995;113:1277-1280.
ABSTRACT
Localization and Quantitation of Blood-Retinal Barrier Breakdown in Experimental Proliferative Vitreoretinopathy
Ando et al.
Arch Ophthalmol 1994;112:117-122.
ABSTRACT
Treatment With Intravitreal Steroid Reduces Blood-Retinal Barrier Breakdown due to Retinal Photocoagulation
Wilson et al.
Arch Ophthalmol 1992;110:1155-1159.
ABSTRACT
Clinical Risk Factors for Proliferative Vitreoretinopathy
Cowley et al.
Arch Ophthalmol 1989;107:1147-1151.
ABSTRACT
The Role of Breakdown of the Blood-Retinal Barrier in Cell-Injection Models of Proliferative Vitreoretinopathy
Sen et al.
Arch Ophthalmol 1988;106:1291-1294.
ABSTRACT
|
