Anterior segment fluorophotometry in acute anterior uveitis
I. R. Fearnley, D. J. Spalton and S. E. Smith
Department of Ophthalmology, St Thomas' Hospital, London, England.
Anterior segment fluorophotometry was used to assess the severity of
blood-aqueous barrier disruption in 25 patients with acute anterior
uveitis. The results indicated that HLA-B27-positive patients had a more
severe inflammation than did HLA-B27-negative patients, which was not
discernible when judged by clinical signs and symptoms. Follow-up studies
showed that the blood-aqueous barrier was disturbed for longer than the
clinical signs indicated, and sometimes a temporary subclinical relapse was
demonstrated on early withdrawal of topical therapy. The blood-aqueous
barrier appeared to be restored after each attack of acute anterior uveitis
in the majority of patients, with no evidence of progressive damage from
repeated attacks. Our results indicated that fluorophotometry provides an
objective and sensitive method of assessing anterior uveitis.
