This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Model Study

Nancy H. Kolodny, PhD; Evangelos S. Gragoudas, MD; Donald J. D'Amico, MD; Susan J. Kohler, PhD; Johanna M. Seddon, MD; Elizabeth J. Murphy; Christina Yun; Daniel M. Albert, MD

Arch Ophthalmol. 1987;105(11):1532-1536.

Abstract
• Clinical evaluation of uveal melanomas by magnetic resonance imaging (MRI) techniques depends on developing an understanding of the appearance of these tumors in magnetic resonance (MR) images. We have determined MR characteristics of uveal melanomas by proton (¹H) and sodium 23 MRI of freshly enucleated human eyes at 1.5 tesla. The MR images were obtained using two-turn proton and ²³Na surface coils, designed to both transmit and receive the radiofrequency signal. Proton MRI techniques included saturation recovery and spin echo; the gradient-recalled echo technique was used for ²³Na MRI. Proton and ²³Na MR images provide complementary information; contrast between intraocular tumors and vitreous, lens, or subretinal hemorrhage may be varied by using MR pulse sequences that emphasize tissues based on T₁, T₂, proton, or sodium density values. A combination of proton and ²³Na MRI provides differentiation between normal ocular structures and intraocular tumors, as well as associated complications, such as retinal detachments and subretinal hemorrhages.

Author Affiliations
From the Howe Laboratory of Ophthalmology (Drs Kolodny, D'Amico, and Albert) and Retina Service (Drs Gragoudas, D'Amico, and Seddon), Massachusetts Eye and Ear Infirmary, Boston; Department of Ophthalmology, Harvard Medical School, Boston (Drs Kolodny, Gragoudas, D'Amico, Seddon, and Albert); Magnetic Resonance Imaging Facility, Massachusetts Institute of Technology, Cambridge (Drs Kolodny and Kohler); and Department of Chemistry, Wellesley College, Wellesley, Mass (Dr Kolodny and Mss Murphy and Yun).

Footnotes
Accepted for publication July 24, 1987.

Reprint requests to Retina Service, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 (Dr Gragoudas).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Role of Fat-Suppression Technique and Gadopentetate Dimeglumine in Magnetic Resonance Imaging Evaluation of Intraocular Tumors and Simulating Lesions
De Potter et al.
Arch Ophthalmol 1994;112:340-348.
ABSTRACT