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Long-term Effects of Topically Applied Epinephrine on the Blood-Ocular Barrier in Humans
Kensaku Miyake, MD;
Yoshiko Miyake, MD;
Ryoko Kuratomi, PhD
Arch Ophthalmol. 1987;105(10):1360-1363.
Abstract
• Epinephrine (1.25%) was applied topically twice daily to both eyes of 22 patients with glaucoma or ocular hypertension. Half of these patients received topical indomethacin (0.5%) three times daily in one eye; the other half received indomethacin placebo under the same regimen. Blood-aqueous and blood-retinal barrier functions were determined by aqueous and vitreous fluorophotometry before and 1, 2, 3, and 7 months after initiation of treatment. Epinephrineinduced disruption of the blood-aqueous barrier, noted at two months, apparently remained constant until the completion of the study. At months 2, 3, and 7, indomethacin significantly inhibited this disruption. The blood-retinal barrier was unaffected. These results bear on the hypotensive mechanism of topically applied epinephrine.
Author Affiliations
From the Shohzankai Medical Foundation, Miyake Eye Hospital, Nagoya, Japan.
Footnotes
Accepted for publication June 18, 1987.
Reprint requests to Shohzankai Medical Foundation, Miyake Eye Hospital, 1070-Kami 5, Higashiozone-cho, Kita-ku, Nagoya 462, Japan (Dr K. Miyake).
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