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I. Breakdown of Bruch's Membrane

Ayala Pollack, MD; Gary E. Korte, PhD; Ari L. Weitzner; Paul Henkind, MD, PhD

Arch Ophthalmol. 1986;104(9):1372-1376.

Abstract
• Previous observations on rats suggested that subretinal neovascularization does not require a prior break in Bruch's membrane (BM).^1-3 We verified this observation by using scanning electron microscopy to examine large expanses of BM that became exposed following ophthalmoscopically white krypton laser burns. Bruch's membrane appeared intact in the acute phase after injury. Subsequently, slitlike defects in BM were associated with penetrating choroidal capillaries. These observations were consistent with transmission electron microscopic findings of cellular protrusions arising from the choriocapillary endothelial cells and from regenerating retinal pigment epithelial (RPE) cells invading BM. These cellformed defects in BM differed from thermal defects in appearance, size, and onset of occurrence. Endothelial cells penetrated all layers of BM, including the RPE basement membrane. We conclude that (1) endothelial cells can erode their own basement membrane and the RPE basement membrane, and (2) krypton laser burns with or without immediate rupture of BM induce cellular activity that may result in defects in BM.

Author Affiliations
From the Eye Research Laboratory, Department of Ophthalmology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY. Dr Pollack is on leave from Kaplan Hospital, Rehovot, Israel, and the Hebrew University, Hadassah Medical School, Jerusalem.

Footnotes
Accepted for publication March 27, 1986.

Reprint requests to the Department of Ophthalmology, Albert Einstein College of Medicine, Montefiore Medical Center, 111 E 210th St, Bronx, NY 10467 (Dr Pollack).

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